« Previous
Next »
Fertility and Sterility
Volume 95, Issue 1
, Pages 105-109
, January 2011
Protamine 1 to protamine 2 ratio correlates with dynamic aspects of DNA fragmentation in human sperm
References
- . Protamines and male infertility. Hum Reprod Update. 2006;12:417–435
- Protamine 2 precursors (Pre-P2), protamine 1 to protamine 2 ratio (P1/P2), and assisted reproduction outcome. Fertil Steril. 2009;91:715–722
- . Ability of hamster spermatozoa to digest their own DNA. Biol Reprod. 2003;69:2029–2035
- . DNA integrity in human spermatozoa: relationships with semen quality. J Androl. 2000;21:33–44
- . DNA integrity is compromised in protamine-deficient human sperm. J Androl. 2005;26:741–748
- Protamine 2 precursors, protamine 1/protamine 2 ratio, DNA integrity and other sperm parameters in infertile patients. Hum Reprod. 2006;21:2084–2089
- . Data analysis of two in vivo fertility studies using sperm chromatin structure assay-derived DNA fragmentation index vs. pregnancy outcome. Fertil Steril. 2008;90:1229–1231
- Dynamics of sperm DNA fragmentation in domestic animals II. The stallion. Theriogenology. 2007;68:1240–1250
- . Sperm deoxyribonucleic acid fragmentation dynamics in fertile donors. Fertil Steril. 2009;92:170–173
- DNA fragmentation dynamics in fresh versus frozen thawed plus gradient-isolated human spermatozoa. Syst Biol Reprod Med. 2010;56:27–36
- Halosperm is an easy, available, and cost-effective alternative for determining sperm DNA fragmentation. Fertil Steril. 2005;84:860
- Presence of endogenous nicks in DNA of ejaculated human spermatozoa and its relationship to chromomycin A3 accessibility. Biol Reprod. 1995;52:864–867
- The effects of age on DNA fragmentation, chromatin packaging and conventional semen parameters in spermatozoa of oligoasthenoteratozoospermic patients. J Assist Reprod Genet. 2007;24:437–443
- DNA damage in human spermatozoa is highly correlated with the efficiency of chromatin remodeling and the formation of 8-hydroxy-2'-deoxyguanosine, a marker of oxidative stress. Biol Reprod. 2009;81:517–524
- . Correlation of sperm DNA damage with protamine deficiency in Iranian subfertile men. Reprod Biomed Online. 2009;18:479–485
- . Transport and fate of spermatozoa after insemination of cattle. J Dairy Sci. 1987;70:1487–1503
- . Sperm transport in the female reproductive tract. Hum Reprod Update. 2006;12:23–37
- . Biological and clinical significance of DNA damage in the male germ line. Int J Androl. 2009;32:46–56
- Sperm protamine 1/protamine 2 ratios are related to in vitro fertilization pregnancy rates and predictive of fertilization ability. Fertil Steril. 2006;86:1408–1415
- Sperm chromatin structure assay as an independent predictor of fertility in vivo: a case-control study. Int J Androl. 2010;33:e221–e227
- . Sperm chromatin structure assay parameters measured after density gradient centrifugation are not predictive for the outcome of ART. Hum Reprod. 2008;23:4–10
- . Sperm chromatin structure assay parameters are not related to fertilization rates, embryo quality, and pregnancy rates in in vitro fertilization and intracytoplasmic sperm injection, but might be related to spontaneous abortion rates. Fertil Steril. 2008;90:352–359
- . Do sperm DNA integrity tests predict pregnancy with in vitro fertilization?. Fertil Steril. 2008;89:823–831
- . Oxidative stress: a common factor in testicular dysfunction. J Androl. 2008;29:488–498
- . Expression of the HSPA2 gene in ejaculated spermatozoa from adolescents with and without varicocele. Fertil Steril. 2006;86:1659–1663
- . Characteristics of human chromatin structure following an episode of influenza and high fever: a case study. J Androl. 2000;21:739–746
- . Segregation of chromosomes in sperm of reciprocal translocation carriers: a review. Cytogenet Genome Res. 2005;111:281–290
- . Cytogenetic determinants of male fertility. Hum Reprod Update. 2008;14:379–390
- Study of two markers of apoptosis and meiotic segregation in ejaculated sperm of chromosomal translocation carrier patients. Hum Reprod. 2006;21:685–693
- DNA fragmentation and meiotic segregation in sperm of carriers of a chromosomal structural abnormality. Fertil Steril. 2009;92:583–589
- . Sperm DNA fragmentation: threshold value in male fertility. Hum Reprod. 2005;20:3446–3451
- . Varicoceles: the diagnostic dilemma. J Androl. 2008;29:143–146
- Simple determination of human sperm DNA fragmentation with an improved sperm chromatin dispersion test. Fertil Steril. 2005;84:833–842
- Infertile men with varicocele show a high relative proportion of sperm cells with intense nuclear damage level, evidenced by the sperm chromatin dispersion test. J Androl. 2006;27:106–111
- . Decreased sperm DNA fragmentation after surgical varicocelectomy is associated with increased pregnancy rate. J Urol. 2010;183:270–274
- . Poor semen quality and ROS-TAC scores in patients with idiopathic infertility. Urol Int. 2008;81:263–270
A.G-P. has nothing to disclose. J.M-H. has nothing to disclose. M.O-B. has nothing to disclose. C.A. has nothing to disclose. M.J.A. has nothing to disclose. J.N. has nothing to disclose. C.J. has nothing to disclose. K.C. has nothing to disclose. J.G. has nothing to disclose. J.B. has nothing to disclose.
A.G-P. and J.M-H. contributed equally to this work.
Supported by the Fondo de Investigación Sanitaria (FIS) (PI051834, PI080623), Generalitat de Catalunya (2009 SGR 1107), Ministerio de Ciencia y Tecnología (MCYT) (BFU 2007-66340/BFI), and Càtedra de Recerca Eugin-UAB.
PII: S0015-0282(10)01006-X
doi: 10.1016/j.fertnstert.2010.06.053
© 2011 American Society for Reproductive Medicine. All rights reserved.
« Previous
Next »
Fertility and Sterility
Volume 95, Issue 1
, Pages 105-109
, January 2011

