Fertility and Sterility
Volume 95, Issue 1 , Pages 363-365, January 2011

SEPT12 deficiency causes sperm nucleus damage and developmental arrest of preimplantation embryos

  • Ying-Hung Lin, Ph.D.

      Affiliations

    • Graduate Institute of Basic Medical Sciences, National Cheng Kung University, College of Medicine, Tainan, Taiwan
    • Department of Obstetrics and Gynecology, National Cheng Kung University, College of Medicine, Tainan, Taiwan
    • ,
  • Chuan-Kai Chou, M.Sc.

      Affiliations

    • National Laboratory Animal Center, Taipei, Taiwan
    • ,
  • Yu-Ching Hung, M.Sc.

      Affiliations

    • National Laboratory Animal Center, Taipei, Taiwan
    • ,
  • I-Shing Yu, Ph.D.

      Affiliations

    • Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    • ,
  • Hsien-An Pan, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, National Cheng Kung University, College of Medicine, Tainan, Taiwan
    • ,
  • Shu-Wha Lin, Ph.D.

      Affiliations

    • Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    • ,
  • Pao-Lin Kuo, M.D.

      Affiliations

    • Graduate Institute of Basic Medical Sciences, National Cheng Kung University, College of Medicine, Tainan, Taiwan
    • Department of Obstetrics and Gynecology, National Cheng Kung University, College of Medicine, Tainan, Taiwan
    • Corresponding Author InformationReprint requests: Pao-Lin Kuo, M.D., Division of Genetics, Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, 138 Sheng-Li Road, Tainan, Taiwan 704 (FAX: 886-6-276-6185).

Received 16 March 2010; received in revised form 2 July 2010; accepted 12 July 2010. published online 31 August 2010.

Oocytes fertilized with spermatozoa obtained from Septin 12+/– chimeric mice failed to develop beyond the morula stage after IVF and intracytoplasmic sperm injection because of significant DNA defects in the spermatozoa. Given that SEPT12 is expressed at the edge of the sperm nucleus in both humans and mice, we hypothesized the vital roles of Septin 12 in sperm head shaping, nuclear DNA condensation, and early embryonic development.

Key Words: Septin 12, sperm nucleus damage

 

 Y-H.L. has nothing to disclose. C-K.C. has nothing to disclose. Y-C.H. has nothing to disclose. I-S.Y. has nothing to disclose. H-A.P. has nothing to disclose. S-W.L. has nothing to disclose. P-L.K. has nothing to disclose.

 Supported by grants from the National Science Council of the Republic of China (NSC96-2314-B-006-003; NSC97-2622-B-006-002-CC1; NSC98-2622-B-006-004- CC1).

PII: S0015-0282(10)02170-9

doi:10.1016/j.fertnstert.2010.07.1064

Fertility and Sterility
Volume 95, Issue 1 , Pages 363-365, January 2011

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