Fertility and Sterility
Volume 95, Issue 1 , Pages 363-365 , January 2011

SEPT12 deficiency causes sperm nucleus damage and developmental arrest of preimplantation embryos

  • Ying-Hung Lin, Ph.D.

      Affiliations

    • Graduate Institute of Basic Medical Sciences, National Cheng Kung University, College of Medicine, Tainan, Taiwan
    • Department of Obstetrics and Gynecology, National Cheng Kung University, College of Medicine, Tainan, Taiwan
    • ,
  • Chuan-Kai Chou, M.Sc.

      Affiliations

    • National Laboratory Animal Center, Taipei, Taiwan
    • ,
  • Yu-Ching Hung, M.Sc.

      Affiliations

    • National Laboratory Animal Center, Taipei, Taiwan
    • ,
  • I-Shing Yu, Ph.D.

      Affiliations

    • Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    • ,
  • Hsien-An Pan, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, National Cheng Kung University, College of Medicine, Tainan, Taiwan
    • ,
  • Shu-Wha Lin, Ph.D.

      Affiliations

    • Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    • ,
  • Pao-Lin Kuo, M.D.

      Affiliations

    • Graduate Institute of Basic Medical Sciences, National Cheng Kung University, College of Medicine, Tainan, Taiwan
    • Department of Obstetrics and Gynecology, National Cheng Kung University, College of Medicine, Tainan, Taiwan
    • Corresponding Author InformationReprint requests: Pao-Lin Kuo, M.D., Division of Genetics, Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, 138 Sheng-Li Road, Tainan, Taiwan 704 (FAX: 886-6-276-6185).

Received 16 March 2010 ,Revised 2 July 2010 ,Accepted 12 July 2010.

References 

  1. Hall PA, Russell SE. The pathobiology of the septin gene family. J Pathol. 2004;204:489–505
  2. Ihara M, Kinoshita A, Yamada S, Tanaka H, Tanigaki A, Kitano A, et al. Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoa. Dev Cell. 2005;8:343–352
  3. Kissel H, Georgescu MM, Larisch S, Manova K, Hunnicutt GR, Steller H. The Sept4 septin locus is required for sperm terminal differentiation in mice. Dev Cell. 2005;8:353–364
  4. Sugino Y, Ichioka K, Soda T, Ihara M, Kinoshita M, Ogawa O, et al. Septins as diagnostic markers for a subset of human asthenozoospermia. J Urol. 2008;180:2706–2709
  5. Lin YH, Lin YM, Wang YY, Yu IS, Lin YW, Wang YH, et al. The expression level of septin12 is critical for spermiogenesis. Am J Pathol. 2009;174:1857–1868
  6. Talebi AR, Moein MR, Tabibnejad N, Ghasemzadeh J. Effect of varicocele on chromatin condensation and DNA integrity of ejaculated spermatozoa using cytochemical tests. Andrologia. 2008;40:245–251
  7. Chu PC, Wang TY, Lu YT, Chou CK, Yang YC, Chang MS. Involvement of p29 in DNA damage responses and Fanconi anemia pathway. Carcinogenesis. 2009;30:1710–1716
  8. Cho C, Willis WD, Goulding EH, Jung-Ha H, Choi YC, Hecht NB, et al. Haploinsufficiency of protamine-1 or -2 causes infertility in mice. Nat Genet. 2001;28:82–86

 Y-H.L. has nothing to disclose. C-K.C. has nothing to disclose. Y-C.H. has nothing to disclose. I-S.Y. has nothing to disclose. H-A.P. has nothing to disclose. S-W.L. has nothing to disclose. P-L.K. has nothing to disclose.

 Supported by grants from the National Science Council of the Republic of China (NSC96-2314-B-006-003; NSC97-2622-B-006-002-CC1; NSC98-2622-B-006-004- CC1).

PII: S0015-0282(10)02170-9

doi: 10.1016/j.fertnstert.2010.07.1064

Fertility and Sterility
Volume 95, Issue 1 , Pages 363-365 , January 2011

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