GnRH-agonist induced depressive and anxiety symptoms during in vitro fertilization–embryo transfer cycles
To determine whether the use of a GnRH agonist inducing a hypogonadic state during IVF-ET cycles induces negative mood symptoms, we conducted a prospective randomized study in 108 women comparing two different controlled ovarian stimulation protocols. A significant phase effect was observed for depression and anxiety symptoms during IVF-ET cycles reflecting an increase in symptoms between the hypogonadal phase and the peak in gonadotropin stimulation; however, the hypogonadal phase induced by the GnRH agonist was not associated with a significant increase in any of the studied mood parameters.
Key Words: In vitro fertilization, GnRH agonist, estradiol, progesterone, depression, anxiety, mood
M.B. has nothing to disclose. F.A. has nothing to disclose. I.A. has nothing to disclose. I.B.A. has nothing to disclose. Y.Y. has nothing to disclose. S.S. has nothing to disclose. A.A. has nothing to disclose. A.W. has nothing to disclose.
M.B. and F.A. contributed equally to this article.
Supported by the National Institute for Psychobiology in Israel.
PII: S0015-0282(10)02199-0
doi:10.1016/j.fertnstert.2010.07.1073
© 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
