Fertility and Sterility
Volume 95, Issue 1 , Pages 307-309 , January 2011

GnRH-agonist induced depressive and anxiety symptoms during in vitro fertilization–embryo transfer cycles

Presented in part at the 13th Israel Society of Biological Psychiatry, Hagoshrim, Israel, March 3-5, 2009.

  • Miki Bloch, M.D.

      Affiliations

    • Department of Psychiatry, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    • Corresponding Author InformationReprint requests: Miki Bloch, M.D., Psychiatric Department, Tel Aviv Sourasky Medical Center, 6 Weizman St., Tel Aviv, Israel 64239 (FAX: 97236975774).
    • ,
  • Foad Azem, M.D.

      Affiliations

    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    • IVF Unit, Lis Women’s Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    • ,
  • Inbar Aharonov, M.Sc.

      Affiliations

    • Department of Psychiatry, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    • ,
  • Irit Ben Avi, Ph.D.

      Affiliations

    • Department of Psychiatry, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    • ,
  • Yaron Yagil, Ph.D.

      Affiliations

    • Department of Psychiatry, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    • ,
  • Shaul Schreiber, M.D.

      Affiliations

    • Department of Psychiatry, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    • ,
  • Ami Amit, M.D.

      Affiliations

    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    • IVF Unit, Lis Women’s Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    • ,
  • Abraham Weizman, M.D.

      Affiliations

    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    • Geha Mental Health Center and the Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Petah Tikva, Israel

Received 16 June 2010 ,Revised 16 July 2010 ,Accepted 16 July 2010.

References 

  1. Kee BS, Jung BJ, Lee SH. A study on psychological strain in IVF patients. J Assist Reprod Genet. 2000;17:445–448
  2. Beaurepaire J, Jones M, Thiering P, Saunders D, Tennant C. Psychosocial adjustment to infertility and its treatment: male and female responses at different stages of IVF/ET treatment. J Psychosom Res. 1994;38:229–240
  3. Olivius C, Friden B, Borg G, Bergh C. Why do couples discontinue in vitro fertilization treatment? A cohort study. Fertil Steril. 2004;81:258–261
  4. Shalev E, Leung PC. Gonadotropin-releasing hormone and reproductive medicine. J Obstet Gynaecol Can. 2003;25:98–113
  5. Patten SB, Barbui C. Drug-induced depression: a systematic review to inform clinical practice. Psychother Psychosom. 2004;73:207–215
  6. Henzl MR, Corson SL, Moghissi K, Buttram VC, Berqvist C, Jacobson J. Administration of nasal nafarelin as compared with oral danazol for endometriosis. A multicenter double-blind comparative clinical trial. N Engl J Med. 1988;318:485–489
  7. Erickson LD, Ory SJ. GnRH analogues in the treatment of endometriosis. Obstet Gynecol Clin North Am. 1989;16:123–145
  8. Schmidt PJ, Steinberg EM, Negro PP, Haq N, Gibson C, Rubinow DR. Pharmacologically induced hypogonadism and sexual function in healthy young women and men. Neuropsychopharmacology. 2009;34:565–576
  9. Warnock JK, Bundren JC, Morris DW. Depressive symptoms associated with gonadotropin-releasing hormone agonists. Depress Anxiety. 1998;7:171–177
  10. Warnock JK, Bundren JC, Morris DW. Depressive mood symptoms associated with ovarian suppression. Fertil Steril. 2000;74:984–986
  11. Küpker W, Felberbaum RE, Krapp M, Schill T, Malik E, Diedrich K. Use of GnRH antagonists in the treatment of endometriosis. Reprod Biomed. 2002;5:12–16
  12. Toren P, Dor J, Mester R, Mozes T, Blumensohn R, Rehavi M, et al. Depression in women treated with a gonadotropin-releasing hormone agonist. Biol Psychiatry. 1996;39:378–382
  13. Derogatis LR, Melisaratos N. The Brief Symptom Inventory: an introductory report. Psychol Med. 1983;13:595–605
  14. Spielberger CD, Gorsuch RL, Lushene RE. Test manual for the State-Trait Anxiety Inventory. Palo Alto (CA): Consulting Psychologists Press; 1970;
  15. Spielberger CD, Gorsuch RL, Lushene R, Vagg PR, Jacobs GA. Manual for the state-trait inventory. Palo Alto (CA): Consulting Psychologists Press; 1983;
  16. Radloff LS. The CES-D Scale: a self-report depression scale for research in the general population. J Applied Psychol Measurement. 1977;1:385–401
  17. Pandya R, Metz L, Patten SB. Predictive value of the CES-D in detecting depression among candidates for disease-modifying multiple sclerosis treatment. Psychosomatics. 2005;46:131–134
  18. Young EA, Midgley AR, Carlson NE, Brown MB. Alteration in the hypothalamic-pituitary-ovarian axis in depressed women. Arch Gen Psychiatry. 2000;57:1157–1162
  19. McEwen BS, Alves SE. Estrogen actions in the central nervous system. Endocr Rev. 1999;20:279–307
  20. Rubinow DR, Schmidt PJ, Roca CA. Estrogen-serotonin interactions: implications for affective regulation. Biol Psychiatry. 1998;44:839–850
  21. Weizman A, Morgenstern H, Rehavi M. Up-regulatory effect of triphasic oral contraceptive on platelet 3H-imipramine binding sites. Psychiatry Res. 1988;23:23–27
  22. Schmidt PJ, Nieman L, Danaceau MA, Tobin MB, Roca CA, Murphy JH, et al. Estrogen replacement in perimenopause-related depression: a preliminary report. Am J Obstet Gynecol. 2000;183:414–420
  23. Freeman EW, Sammel MD, Lin H, Nelson DB. Associations of hormones and menopausal status with depressed mood in women with no history of depression. Arch Gen Psychiatry. 2006;63:375–382
  24. Cohen LS, Soares CN, Vitonis AF, Otto MW, Harlow BL. Risk for new onset of depression during the menopausal transition: the Harvard study of moods and cycles. Arch Gen Psychiatry. 2006;63:385–390
  25. Halbreich U. Gonadal hormones, reproductive age, and women with depression. Arch Gen Psychiatry. 2000;57:1163–1164
  26. Schmidt PJ, Rubinow DR. Sex hormones and mood in the perimenopause. Ann N Y Acad Sci. 2009;1179:70–85
  27. Deecher D, Andree TH, Sloan D, Schechter LE. From menarche to menopause: exploring the underlying biology of depression in women experiencing hormonal changes. Psychoneuroendocrinology. 2008;33:3–17
  28. Gavin NI, Gaynes BN, Lohr KN, Meltzer-Brody S, Gartlehner G, Swinson T. Perinatal depression: a systematic review of prevalence and incidence. Obstet Gynecol. 2005;106:1071–1083

 M.B. has nothing to disclose. F.A. has nothing to disclose. I.A. has nothing to disclose. I.B.A. has nothing to disclose. Y.Y. has nothing to disclose. S.S. has nothing to disclose. A.A. has nothing to disclose. A.W. has nothing to disclose.

 M.B. and F.A. contributed equally to this article.

 Supported by the National Institute for Psychobiology in Israel.

PII: S0015-0282(10)02199-0

doi: 10.1016/j.fertnstert.2010.07.1073

Fertility and Sterility
Volume 95, Issue 1 , Pages 307-309 , January 2011

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