Microdose gonadotropin-releasing hormone agonist in the absence of exogenous gonadotropins is not sufficient to induce multiple follicle development

(A–C) Curves created by serial determinations of hormone values were plotted for each subject to characterize the magnitude and duration of rise over 14 days compared with baseline values. (A) Follicle-stimulating hormone (FSH) levels over time. (B) Luteinizing hormone (LH) levels over time. (C) Estradiol levels over time. (D) Mean follicle diameter of largest follicle. Total number and maximum mean diameters of ovarian follicles were plotted over a 14-day period. All visible ovarian follicles were measured in two dimensions daily for a total of 14 days from the initiation of LA. All curves started at “study visit 0,” which corresponded to baseline values obtained on cycle day 3. “Study visit 1” reflected values obtained on discontinuation of the OC pills. Study visits 2 through 14 represented daily morning values after initiation of LA.