Fertility and Sterility
Volume 95, Issue 5 , Pages 1677-1683 , April 2011

How effective is in vitro fertilization, and how can it be improved?

  • Louise M. Stewart, B.Sc.(Hons), Grad.Dip.P.H.

      Affiliations

    • School of Population Health, The University of Western Australia, Crawley, Western Australia, Australia
    • Corresponding Author InformationReprint requests: Louise M. Stewart, B.Sc.(Hons), Grad.Dip.P.H., School of Population Health, University of Western Australia, M431, 35 Stirling Highway, Crawley, Western Australia 6009, Australia.
    • ,
  • C. D’Arcy J. Holman, M.P.H., Ph.D., F.A.F.P.H.M.

      Affiliations

    • School of Population Health, The University of Western Australia, Crawley, Western Australia, Australia
    • ,
  • Roger Hart, M.D., C.R.E.I.

      Affiliations

    • School of Women’s and Infants Health, The University of Western Australia and Fertility Specialists of Western Australia, Crawley, Western Australia, Australia
    • ,
  • Judith Finn, Ph.D., R.N.

      Affiliations

    • Discipline of Emergency Medicine, The University of Western Australia, Crawley, Western Australia, Australia
    • ,
  • Qun Mai, M.B.B.S., M.P.H.

      Affiliations

    • School of Population Health, The University of Western Australia, Crawley, Western Australia, Australia
    • ,
  • David B. Preen, Ph.D.

      Affiliations

    • School of Population Health, The University of Western Australia, Crawley, Western Australia, Australia

Received 18 October 2010 ,Revised 31 December 2010 ,Accepted 15 January 2011.

References 

  1. Malizia BA, Hacker MR, Penzias AS. Cumulative live-birth rates after in vitro fertilization. N Engl J Med. 2009;360:236–243
  2. Elizur SE, Lerner-Geva L, Levron J, Shulman A, Bider D, Dor J. Cumulative live birth rate following in vitro fertilization: study of 5,310 cycles. Gynecol Endocrinol. 2006;22:25–30
  3. Engmann L, Maconochie N, Bekir JS, Jacobs HS, Tan SL. Cumulative probability of clinical pregnancy and live birth after a multiple cycle IVF package: a more realistic assessment of overall and age-specific success rates?. Br J Obstet Gynaecol. 1999;106:165–170
  4. Olivius K, Friden B, Lundin K, Bergh C. Cumulative probability of live birth after three in vitro fertilization/intracytoplasmic sperm injection cycles. Fertil Steril. 2002;77:505–510
  5. Sharma V, Allgar V, Rajkhowa M. Factors influencing the cumulative conception rate and discontinuation of in vitro fertilization treatment for infertility. Fertil Steril. 2002;78:40–46
  6. Witsenburg C, Dieben S, Van der Westerlaken L, Verburg H, Naaktgeboren N. Cumulative live birth rates in cohorts of patients treated with in vitro fertilization or intracytoplasmic sperm injection. Fertil Steril. 2005;84:99–107
  7. Moragianni VA, Penzias AS. Cumulative live-birth rates after assisted reproductive technology. Curr Opin Obstet Gynecol. 2010;22:189–192
  8. Holman CD, Bass AJ, Rouse IL, Hobbs MS. Population-based linkage of health records in Western Australia: development of a health services research linked database. Aust N Z J Pub Health. 1999;23:453–459
  9. Stolwijk AM, Hamilton CJ, Hollanders JM, Bastiaans LA, Zielhuis GA. A more realistic approach to the cumulative pregnancy rate after in-vitro fertilization. Hum Reprod. 1996;11:660–663
  10. Stern JE, Brown MB, Luke B, Wantman E, Lederman A, Missmer SA, et al. Calculating cumulative live-birth rates from linked cycles of assisted reproductive technology (ART): data from the Massachusetts SART CORS. Fertil Steril. 2010;94:1334–1340
  11. Dor J, Seidman DS, Ben-Shlomo I, Levran D, Ben-Rafael Z, Mashiach S. Cumulative pregnancy rate following in-vitro fertilization: the significance of age and infertility aetiology. Hum Reprod. 1996;11:425–428
  12. Fukuda J, Kumagai J, Kodama H, Murata M, Kawamura K, Tanaka T. Upper limit of the number of IVF-ET treatment cycles in different age groups, predicted by cumulative take-home baby rate. Acta Obstet Gynecol Scand. 2001;80:71–73
  13. Stolwijk AM, Wetzels AM, Braat DD. Cumulative probability of achieving an ongoing pregnancy after in-vitro fertilization and intracytoplasmic sperm injection according to a woman’s age, subfertility diagnosis and primary or secondary subfertility. Hum Reprod. 2000;15:203–209
  14. Webb S. In vitro fertilisation and related procedures in Western Australia 1983–1987. A demographic, clinical and economic evaluation of participants and procedures. Perth: Health Department of Western Australia; 1988;
  15. Chambers GM, Sullivan EA, Ishihara O, Chapman MG, Adamson GD. The economic impact of assisted reproductive technology: a review of selected developed countries. Fertil Steril. 2009;91:2281–2294
  16. Brandes M, van der Steen JO, Bokdam SB, Hamilton CJ, de Bruin JP, Nelen WL, et al. When and why do subfertile couples discontinue their fertility care? A longitudinal cohort study in a secondary care subfertility population. Hum Reprod. 2009;24:3127–3135
  17. Olivius C, Friden B, Borg G, Bergh C. Why do couples discontinue in vitro fertilization treatment? a cohort study. Fertil Steril. 2004;81:258–261
  18. Van den Broeck U, Holvoet L, Enzlin P, Bakelants E, Demyttenaere K, D’Hooghe T. Reasons for dropout in infertility treatment. Gynecol Obstet Invest. 2009;68:58–64
  19. Verberg MF, Eijkemans MJ, Heijnen EM, Broekmans FJ, de Klerk C, Fauser BC, et al. Why do couples drop-out from IVF treatment? A prospective cohort study. Hum Reprod. 2008;23:2050–2055
  20. Lintsen AM, Eijkemans MJ, Hunault CC, Bouwmans CA, Hakkaart L, Habbema JD, et al. Predicting ongoing pregnancy chances after IVF and ICSI: a national prospective study. Hum Reprod. 2007;22:2455–2462

 L.M.S. has nothing to disclose. C.D.J.H. has nothing to disclose. R.H. is Medical Director of Fertility Specialists of Western Australia and Medical Director of Fertility Specialists South. He is a consultant to the Fertility Advisory Board Merck Serono Australia and Fertility Advisory Board Schering-Plough Australia and received industry sponsorship to attend the annual meeting of the European Society of Human Reproduction and Embryology in 2009. J.F. has nothing to disclose. Q.M. has nothing to disclose. D.B.P. has nothing to disclose.

 This study was supported by OSPREY, a capacity building grant from the National Health and Medical Research Council, Australia; project no. 573122. L.M.S. holds an Australian Postgraduate Award from the Australian Government Department of Innovation, Industry, Science and Research.

PII: S0015-0282(11)00164-6

doi: 10.1016/j.fertnstert.2011.01.130

Fertility and Sterility
Volume 95, Issue 5 , Pages 1677-1683 , April 2011

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