Fertility and Sterility
Volume 71, Issue 4 , Pages 697-700 , April 1999

Absence of microdeletions in the Y chromosome in patients with a history of cryptorchidism and azoospermia or oligospermia

Presented at the North East Section of the American Urological Association Meeting, October 18–21, 1998, Toronto, Ontario, Canada.

  • Julian Fagerli, M.D.

      Affiliations

    • Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    • Division of Urologic Surgery.
    • ,
  • Francis X Schneck, M.D.

      Affiliations

    • Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    • Division of Urologic Surgery.
    • ,
  • Peter A Lee, M.D., Ph.D.

      Affiliations

    • Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    • Division of Pediatric Endocrinology, Department of Pediatrics.
    • ,
  • Mark F Bellinger, M.D.

      Affiliations

    • Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    • Division of Urologic Surgery.
    • ,
  • Selma F Witchel, M.D.

      Affiliations

    • Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    • Division of Urologic Surgery.
    • Corresponding Author InformationReprint requests: Selma F. Witchel, M.D., Division of Endocrinology, Children’s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, Pennsylvania 15213 (FAX: 412-692-5834)

Received 19 August 1998 ,Revised 23 November 1998 ,Accepted 23 November 1998.

References 

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  3. Lee PA, O’Leary LA, Songer NJ, Coughlin MT, Bellinger MF, LaPorte RE. Paternity after unilateral cryptorchidism (a controlled study). Pediatrics. 1996;98:676–679
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  9. Andersson M, Page DC, Pettay D, Subrt I, Turleau C, de Grouchy J, et al.  Y autosome translocations and mosaicism in the aetiology of 45,X maleness (assignment of fertility factor to distal Yq11). Hum Genet. 1988;79:2–7
  10. Bardoni B, Zuffardi O, Guioli S, Ballabio A, Simi P, Cavalli P, et al.  A deletion map of the human Yq11 region (implications for the evolution of the Y chromosome and tentative mapping of a locus involved in spermatogenesis). Genomics. 1991;11:443–451
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  14. Pryor JL, Kent-First M, Muallem A, Van Bergen AH, Nolton WE, Meisner L, et al.  Microdeletions in the Y chromosome of infertile men. N Engl J Med. 1997;336:534–539
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  17. Okuyama A, Nonomura N, Nakamura M, Namaki M, Fujioka H, Kiyohara , et al.  Surgical management of undescended testis (retrospective study of potential fertility in 274 cases). J Urol. 1989;142:749–751
  18. Woodhead DM, Pohl DR, Johnson DE. Fertility of patients with solitary testis. J Urol. 1973;100:66–67
  19. Hawkins JR. Genetic determinants of testis development in normal and abnormal individuals. Intersexuality. 1992;38:62–65
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  21. Satokata I, Benson G, Maas R. Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice. Nature. 1995;374:460–463
  22. Rijli F, Matyas R, Pellegrini M, Dierich A, Gruss P, Dolle P, et al.  Cryptorchidism and homeotic transformations of spinal nerves and vertabrae in Hoxa-10 deficient mice. Proc Natl Acad Sci USA. 1995;92:8185–8189
  23. Kolon TF, Weiner JS, Roth DR, Gonzales ET, Lamb DJ. Analysis for alterations of the homeobox gene, HOXA10, in cryptorchid patients (abstract no. 98). In: Program and Abstracts of the 1997 Meeting of the American Academy of Pediatrics. Nov. 1–3, 1997, New Orleans, Louisiana.

☆ Supported by National Institutes of Health grants R01-HD26477 (P.A.L.), R29-HD34808 (S.F.W.), and 5M01-RR-00084 (General Clinical Research Center), and the Genentech Foundation.

PII: S0015-0282(98)00535-4

Fertility and Sterility
Volume 71, Issue 4 , Pages 697-700 , April 1999

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