Fertility and Sterility
Volume 71, Issue 4 , Pages 609-613 , April 1999

A flexible protocol for artificial preparation of the endometrium without prior gonadotropin-releasing hormone agonist suppression in women with functioning ovaries undergoing frozen-thawed embryo transfer cycles

Presented in part at the 54th Annual Meeting of the American Society for Reproductive Medicine, San Francisco, California, October 4–9, 1998.

  • Alex Simon, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel
    • Corresponding Author InformationReprint requests: Alex Simon, M.D., Department of Obstetrics and Gynecology, Hadassah University Hospital, Mount Scopus, P.O. Box 24035, Jerusalem 91240, Israel (FAX: 972-2-5814210)
    • ,
  • Arye Hurwitz, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel
    • ,
  • Murshid Pharhat, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel
    • ,
  • Ariel Revel, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel
    • ,
  • Bat-Sheva Zentner (M.Sc.)

      Affiliations

    • Department of Obstetrics and Gynecology, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel
    • ,
  • Neri Laufer, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel

Received 3 September 1998 ,Revised 17 November 1998 ,Accepted 17 November 1998.

References 

  1. Navot D, Bergh PA, Laufer N. Ovarian hyperstimulation syndrome in novel reproductive technologies (prevention and treatment). Fertil Steril. 1992;58:249–261
  2. Cohen J, DeVane GW, Elsner CW, Kort HI, Mossey JB, Norbury SE, et al.  Cryopreserved zygotes and embryos and endocrinologic factors in the replacement cycle. Fertil Steril. 1988;50:61–67
  3. Testart J, Lassalle B, Belaisch-Allart J, Forman R, Hazout A, Fries N, et al.  Human embryo freezing. Ann NY Acad Sci. 1988;541:532–540
  4. Muasher SJ, Kruithoff C, Simonetti S, Oehninger S, Acosta AA, Jones GS. Controlled preparation of the endometrium with exogenous steroids for the transfer of frozen-thawed pre-embryos in patients with anovulatory or irregular cycles. Hum Reprod. 1991;6:443–445
  5. Van der Auwera I, Meuleman C, Koninckx PR. Human menopausal gonadotrophin increases pregnancy rate in comparison with clomiphene citrate during replacement cycles of frozen/thawed pronucleate ova. Hum Reprod. 1994;9:1556–1560
  6. Birkenfeld A, Beier HM, Schenker GJ. The effect of clomiphene citrate on early embryonic development, endometrium and implantation. Hum Reprod. 1986;1:387–395
  7. Navot D, Anderson TL, Droesch K, Scott RT, Kreiner D, Rosenwaks Z. Hormonal manipulation of endometrial maturation. J Clin Endocrinol Metab. 1989;68:801–807
  8. Younis JS, Simon A, Laufer N. Endometrial preparation—lessons from oocyte donation. Fertil Steril. 1996;66:873–884
  9. Meldrum DR, Wisot A, Hamilton F, Gyttay-Yeo AL, Marr B, Huynh D. Artificial agonadism and hormone replacement for oocyte donation. Fertil Steril. 1989;52:509–511
  10. Remohi J, Gutierrez A, Ruiz A, Simon C, Pellicer A. Long oestradiol replacement in an oocyte donation programme. Hum Reprod. 1995;10:1387–1391
  11. de Ziegler D, Cornel C, Bergeron C, Hazout A, Bouchard P, Frydman R. Controlled preparation of the endometrium with exogenous estradiol and progesterone in women having functioning ovaries. Fertil Steril. 1991;56:851–855
  12. Queenan JT, Ramey JW, Seltman HJ, Seltman HJ, Eure L, Veeck LL, et al.  Transfer of cryopreserved-thawed pre-embryos in a cycle using exogenous steroids without prior gonadotrophin-releasing hormone agonist suppression yields favourable pregnancy results. Hum Reprod. 1997;12:1176–1180
  13. Pattinson HA, Greene CA, Fleetham J, Anderson-Sykes SJ. Exogenous control of the cycle simplifies thawed embryo transfer and results in a pregnancy rate similar to that for natural cycles. Fertil Steril. 1992;58:627–629
  14. Simon A, Hurwitz A, Zentner B, Bdolah Y, Laufer N. Transfer of frozen-thawed embryos in artificially prepared cycles with and without prior gonadotrophin-releasing hormone agonist suppression—a prospective randomized study. Hum Reprod. 1998;13:2712–2717
  15. Ben-Nun I, Shulman A. Induction of artificial endometrial cycles with s.c. oestrogen implants and injectable progesterone in in-vitro fertilization treatment with donated oocytes: a preliminary report. Hum Reprod. 1997;12:2267–2270
  16. Michalas S, Loutradis D, Drakakis P, Kallianidis K, Milingos S, Deligeoroglou E, et al.  A flexible protocol for the induction of recipient endometrial cycles in an oocyte donation programme. Hum Reprod. 1996;11:1063–1066
  17. Testart J, Lassalle B, Belaisch-Allart J, Hazout A, Forman R, Rainborn JD, et al.  High pregnancy rate after early human embryo freezing. Fertil Steril. 1986;46:268–272
  18. Yee B, Lin YP, Chacon RR, Soubra S, Rosen GF, Cassidenti DL. A simplified method of timing frozen embryo transfers. Am J Obstet Gynecol. 1995;172:1844–1848
  19. Lelaidier C, de-Ziegler D, Gaetano J, Hazout A, Fernandez H, Frydman R. Controlled preparation of the endometrium with exogenous oestradiol and progesterone (a novel regimen not using a gonadotrophin-releasing hormone agonist). Hum Reprod. 1992;7:1353–1356
  20. Abdalla HI, Brooks AA, Johnson MR, Kirkland A, Thomas A, Studd JW. Endometrial thickness (a predictor of implantation in ovum recipients?). Hum Reprod. 1994;9:363–365
  21. Bulleti C, de Ziegler D, Flamingi Z, Giacomucci E, Polli V, Bolelli G, et al.  Targeted drug delivery in gynecology (the first uterine pass effect). Hum Reprod. 1997;12:1073–1079
  22. Younis JS, Mordel N, Lewin A, Simon A, Schenker JG, Laufer N. Artificial endometrial preparation for oocyte donation (the effect of oestrogen stimulation on clinical outcome). J Assist Reprod Genet. 1992;9:222–227

PII: S0015-0282(98)00539-1

Fertility and Sterility
Volume 71, Issue 4 , Pages 609-613 , April 1999

Article Tools