What do reproductive-age women who undergo oocyte cryopreservation think about the process as a means to preserve fertility?


      To better understand women's beliefs, priorities, and attitudes toward oocyte cryopreservation, to appreciate the extent of their reproductive education, and to track the reproductive paths of women who chose to undergo oocyte cryopreservation treatment.


      An anonymous 30-question survey.


      Not applicable.


      From 2005–2011, 478 women completed ≥1 oocyte cryopreservation treatment cycle at our center to defer reproduction.



      Main Outcome Measure(s)

      Demographics, motivations, desires, fertility knowledge, and outcomes related to oocyte cryopreservation.


      A total of 183 patients (38%) completed the survey with >80% being aged ≥35 years; white; having no partner at time of oocyte cryopreservation; undergoing oocyte cryopreservation after an optimal reproductive age; feeling they had improved their reproductive future after oocyte cryopreservation and being empowered by the process; aware of age-related infertility; sensing popular media falsely portrayed the upper age limit for natural conception; and recorded lack of partner as the primary rationale for not yet starting a family. Nineteen percent of respondents added that workplace inflexibility contributed to their reproductive dilemma. Half stated they learned about oocyte cryopreservation from a friend; others became aware through a medical provider, the media, and the internet. Most patients (93%) have not yet returned to use their frozen oocytes; 11 stated they had. Overall, 20% reported a successful conception after oocyte cryopreservation.


      Surveying oocyte cryopreservation patients provides a glimpse into the knowledge base and motivations surrounding current female reproductive practices. Oocyte cryopreservation technology may prove to bridge the gap between reproductive prime and when a woman is realistically “ready” to have children.

      Key Words

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        • Martin J.A.
        • Hamilton B.E.
        • Sutton P.D.
        • Ventura S.J.
        • Mathews T.J.
        • Osterman M.J.
        Births: final data for 2008.
        Natl Vital Stat Rep. 2010; 59 (1,3–71)
        • Martin J.A.
        • Hamilton B.E.
        • Ventura S.J.
        • Osterman M.J.
        • Kirmeyer S.
        • Mathews T.J.
        • et al.
        Births: final data for 2009.
        Natl Vital Stat Rep. 2011; 60: 1-70
        • Martin J.A.
        • Hamilton B.E.
        • Ventura S.J.
        • Osterman M.J.K.
        • Wilson E.C.
        • Mathews T.J.
        Births: final data for 2010.
        Natl Vital Stat Rep. 2012; 61: 4-6
        • Matthews T.J.
        • Hamilton B.E.
        Delayed childbearing: more women are having their first child later in life.
        NCHS Data Brief. 2009; 21: 1-8
        • Heck K.E.
        • Schoendorf K.C.
        • Ventura S.J.
        • Kiely J.L.
        Delayed childbearing by education level in the United States, 1969–1994.
        Matern Child Health J. 1997; 1: 81-88
        • Bretherick K.L.
        • Fairbrother N.
        • Avila L.
        • Harbord S.H.
        • Robinson W.P.
        Fertility and aging: do reproductive-aged Canadian women know what they need to know?.
        Fertil Steril. 2010; 93: 2162-2168
        • Van Noord-Zaadstra B.M.
        • Looman C.W.
        • Alsbach H.
        • Habbema J.D.
        • te Velde E.R.
        • Karbaat J.
        Delaying childbearing: effect of age on fecundity and outcome of pregnancy.
        BMJ. 1991; 302: 1361-1365
        • Hassold T.
        • Chiu D.
        Maternal age-specific rates of numerical chromosome abnormalities with special reference to trisomy.
        Hum Genet. 1985; 70: 11-17
        • Gosden R.G.
        Maternal age: a major factor affecting the prospects and outcome of pregnancy.
        Ann N Y Acad Sci. 1985; 442: 45-57
        • Chen C.
        Pregnancy after human oocyte cryopreservation.
        Lancet. 1986; 1: 884-886
        • Chian R.C.
        • Huang J.Y.
        • Tan S.L.
        • Lucena E.
        • Saa A.
        • Rojas A.
        • et al.
        Obstetric and perinatal outcome in 200 infants conceived from vitrified oocytes.
        Reprod Biomed Online. 2008; 16: 608-610
        • Cobo A.
        • Meseguer M.
        • Remohí J.
        • Pellicer A.
        Use of cryo-banked oocytes in an ovum donation programme: a prospective, randomized, controlled, clinical trial.
        Hum Reprod. 2010; 25: 2239-2246
        • Noyes N.
        • Porcu E.
        • Borini A.
        Over 900 oocyte cryopreservation babies born with no apparent increase in congenital anomalies.
        Reprod Biomed Online. 2009; 18: 769-776
        • Noyes N.
        • Knopman J.
        • Labella P.
        • McCaffrey C.
        • Clark-Williams M.
        • Grifo J.
        Oocyte cryopreservation outcomes including pre-cryopreservation and post-thaw meiotic spindle evaluation following slow cooling and vitrification of human oocytes.
        Fertil Steril. 2010; 94: 2078-2082
        • Kuwayama M.
        Highly efficient vitrification for cryopreservation of human oocytes and embryos: the Cryotop method.
        Theriogenology. 2007; 67: 73-80
        • Rienzi L.
        • Romano S.
        • Albricci L.
        • Maggiulli R.
        • Capalbo A.
        • Baroni E.
        • et al.
        Embryo development of fresh “versus” vitrified metaphase II oocytes after ICSI: a prospective randomized sibling-oocyte study.
        Hum Reprod. 2010; 25: 66-73
        • Trokoudes K.M.
        • Pavlides C.
        • Zhang X.
        Comparison outcome of fresh and vitrified donor oocytes in an egg-sharing donation program.
        Fertil Steril. 2011; 95: 1996-2000
        • Hodes-Wertz B.
        • Noyes N.
        • Mullin C.
        • McCaffrey C.
        • Grifo J.A.
        Retrospective analysis of outcomes following transfer of previously cryopreserved oocytes, pronuclear zygotes and supernumerary blastocysts.
        Reprod Biomed Online. 2011; 23: 118-123
        • Grifo J.A.
        • Noyes N.
        Delivery rate using cryopreserved oocytes is comparable to conventional in vitro fertilization using fresh oocytes: potential fertility preservation for female cancer patients.
        Fertil Steril. 2010; 93: 391-396
        • Noyes N.
        • Knopman J.M.
        • Melzer K.
        • Fino M.E.
        • Friedman B.
        • Westphal L.M.
        Oocyte cryopreservation as a fertility preservation measure for cancer patients.
        Reprod Biomed Online. 2010; 24: 24
        • Noyes N.
        • Labella P.A.
        • Grifo J.
        • Knopman J.M.
        Oocyte cryopreservation: a feasible fertility preservation option for reproductive age cancer survivors.
        J Assist Reprod Genet. 2010; 27: 495-499
      1. Practice Committees of the American Society for Reproductive Medicine and the Society for Assisted Reproductive Technology Mature oocyte cryopreservation: a guideline.
        Fertil Steril. 2013; 99: 37-43
        • Rudick B.
        • Opper N.
        • Paulson R.
        • Bendikson K.
        • Chung K.
        The status of oocyte cryopreservation in the United States.
        Fertil Steril. 2010; 94: 2642-2646
        • Peterson B.D.
        • Pirritano M.
        • Tucker L.
        • Lampic C.
        Fertility awareness and parenting attitudes among American male and female undergraduate university students.
        Hum Reprod. 2012; 27: 1375-1382
        • Devine K.
        • Mumford S.
        • Hodes-Wertz B.
        • Druckenmiller S.
        • Propst A.
        • Noyes N.
        Baby budgeting: a cost-effectiveness analysis of elective oocyte cryopreservation as a means to increase live birth rates in women delaying reproduction.
        Fertil Steril. 2012; 98: S7-S8
        • Van Loendersloot L.L.
        • Moolenaar L.M.
        • Mol B.W.
        • Repping S.
        • van der Veen F.
        • Goddijn M.
        Expanding reproductive lifespan: a cost-effectiveness study on oocyte freezing.
        Hum Reprod. 2011; 26: 3054-3060
        • Hirshfeld-Cytron J.
        • van Loendersloot L.L.
        • Mol B.W.
        • Goddijn M.
        • Grobman W.A.
        • Moolenaar L.M.
        • et al.
        Cost-effective analysis of oocyte cryopreservation: stunning similarities but differences remain.
        Hum Reprod. 2012; 27: 3639
        • Rovei V.
        • Gennarelli G.
        • Lantieri T.
        • Casano S.
        • Revelli A.
        • Massobrio M.
        Family planning, fertility awareness and knowledge about Italian legislation on assisted reproduction among Italian academic students.
        Reprod Biomed Online. 2010; 20: 873-879
        • Hashiloni-Dolev Y.
        • Kaplan A.
        • Shkedi-Rafid S.
        The fertility myth: Israeli students' knowledge regarding age-related fertility decline and late pregnancies in an era of assisted reproduction technology.
        Hum Reprod. 2011; 26: 3045-3053
        • Virtala A.
        • Vilska S.
        • Huttunen T.
        • Kunttu K.
        Childbearing, the desire to have children, and awareness about the impact of age on female fertility among Finnish university students.
        Eur J Contracept Reprod Health Care. 2011; 16: 108-115
        • Benzies K.
        • Tough S.
        • Tofflemire K.
        • Frick C.
        • Faber A.
        • Newburn-Cook C.
        Factors influencing women's decisions about timing of motherhood.
        J Obstet Gynecol Neonatal Nurs. 2006; 35: 625-633
        • Tough S.
        • Benzies K.
        • Fraser-Lee N.
        • Newburn-Cook C.
        Factors influencing childbearing decisions and knowledge of perinatal risks among Canadian men and women.
        Matern Child Health J. 2007; 11: 189-198
        • Cook C.
        • Heath F.
        • Thompson R.
        A meta-analysis of response rates in web- or internet-based surveys.
        Educ Psychol Measure. 2000; 60: 15