Bisphenol A is a typical endocrine-disrupting chemical
Fetal testis is a major target of endocrine disruptors
BPA affects fetal testis development
- Howdeshell K.L.
- Furr J.
- Lambright C.R.
- Wilson V.S.
- Ryan B.C.
- Gray Jr., L.E.
New challenges are raised by BPA
How to assess the hazard of bisphenols A, S, and F?
Choice of in Vitro Method
Choice of the Age at Explantation
Choice of the Culture Conditions
- Akingbemi B.T.
- Sottas C.M.
- Koulova A.I.
- Klinefelter G.R.
- Hardy M.P.
BPS and BPF are not safe alternatives to BPA
Effect of BPS and BPF on Testosterone Secretion and Comparison with BPA
- Kubo T.
- Maezawa N.
- Osada M.
- Katsumura S.
- Funae Y.
- Imaoka S.
Effect of BPA, BPS, and BPF on Fetal Leydig Cell–specific Gene Expression
- Akingbemi B.T.
- Sottas C.M.
- Koulova A.I.
- Klinefelter G.R.
- Hardy M.P.
- Silent spring.Riverside Press, Cambridge, Massachusetts1962
- Developmental effects of endocrine-disrupting chemicals in wildlife and humans.Environ Health Perspect. 1993; 101: 378-384
- Synthetic oestrogenic agents without the phenanthrene nucleus.Nature. 1936; 137: 996
- Viable skin efficiently absorbs and metabolizes bisphenol A.Chemosphere. 2011; 82: 424-430
- Human exposures to bisphenol A: mismatches between data and assumptions.Rev Environ Health. 2013; 28: 37-58
- Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A.Environ Health Perspect. 2010; 118: 1055-1070
- Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A.Cien Saude Colet. 2012; 17: 407-434
- Bisphenol-A acts as a potent estrogen via nonclassical estrogen triggered pathways.Mol Cell Endocrinol. 2012; 355: 201-207
- Twenty-four hour human urine and serum profiles of bisphenol a during high-dietary exposure.Toxicol Sci. 2011; 123: 48-57
- Unconjugated bisphenol A cord blood levels in boys with descended or undescended testes.Hum Reprod. 2012; 27: 983-990
- Determination of bisphenol A concentrations in human biological fluids reveals significant early prenatal exposure.Hum Reprod. 2002; 17: 2839-2841
- Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses.Endocr Rev. 2012; 33: 378-455
- Bisphenol A and human health: a review of the literature.Reprod Toxicol. 2013; 42: 132-155
- Bisphenol A and human chronic diseases: current evidences, possible mechanisms, and future perspectives.Environ Int. 2014; 64: 83-90
- In vivo effects of bisphenol A in laboratory rodent studies.Reprod Toxicol. 2007; 24: 199-224
- Nonmonotonic dose responses in studies of endocrine disrupting chemicals: bisphenol a as a case study.Dose Response. 2014; 12: 259-276
- Male reproductive health and environmental xenoestrogens.Environ Health Perspect. 1996; 104: 741-803
- How strong is the evidence of a link between environmental chemicals and adverse effects on human reproductive health?.BMJ. 2004; 328: 447-451
- The impact of a decline in fecundity and of pregnancy postponement on final number of children and demand for assisted reproduction technology.Hum Reprod. 2008; 23: 1312-1319
- Genital anomalies in boys and the environment.Best Pract Res Clin Endocrinol Metab. 2010; 24: 279-289
- Evidence for decreasing quality of semen during past 50 years.BMJ. 1992; 305: 609-613
- Shedding light on the controversy surrounding the temporal decline in human sperm counts: a systematic review.Sci World J. 2014; 2014: 365691
- Decline in semen concentration and morphology in a sample of 26,609 men close to general population between 1989 and 2005 in France.Hum Reprod. 2013; 28: 462-470
- Semen quality trends in French regions are consistent with a global change in environmental exposure.Reproduction. 2014; 147: 567-574
- Testicular cancer trends as “whistle blowers” of testicular developmental problems in populations.Int J Androl. 2007; 30: 198-204
- Cryptorchidism and hypospadias as a sign of testicular dysgenesis syndrome (TDS): environmental connection.Birth Defects Res A Clin Mol Teratol. 2010; 88: 910-919
- Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?.Lancet. 1993; 341: 1392-1395
- Estrogen effects on fetal and neonatal testicular development.Reproduction. 2006; 132: 527-538
- Environmental factors and testicular function.Best Pract Res Clin Endocrinol Metab. 2011; 25: 391-402
- Cryptorchidism and endocrine disrupting chemicals.Mol Cell Endocrinol. 2012; 355: 208-220
- Similar causes of various reproductive disorders in early life.Asian J Androl. 2014; 16: 50-59
- Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects.Hum Reprod. 2001; 16: 972-978
- Environment, testicular dysgenesis and carcinoma in situ testis.Best Pract Res Clin Endocrinol Metab. 2007; 21: 462-478
- Studies on sex differentiation in mammals.Recent Prog Horm Res. 1973; 29: 1-41
- Steroidogenesis in the fetal testis and its susceptibility to disruption by exogenous compounds.Endocr Rev. 2009; 30: 883-925
- Adverse effects of endocrine disruptors on the foetal testis development: focus on the phthalates.Folia Histochem Cytobiol. 2009; 47: S67-74
- “Idiopathic” partial androgen insensitivity syndrome in 28 newborn and infant males: impact of prenatal exposure to environmental endocrine disruptor chemicals?.Eur J Endocrinol. 2011; 165: 579-587
- Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism.J Clin Invest. 2008; 118: 1479-1490
- Androgen action in the masculinization programming window and development of male reproductive organs.Int J Androl. 2010; 33: 279-287
- Effects of dibutyl phthalate in male rabbits following in utero, adolescent, or postpubertal exposure.Toxicol Sci. 2003; 72: 301-313
- In utero exposure to di(n-butyl) phthalate and testicular dysgenesis: comparison of fetal and adult end points and their dose sensitivity.Environ Health Perspect. 2007; 115: 55-61
- Changes in MAPK pathway in neonatal and adult testis following fetal estrogen exposure and effects on rat testicular cells.Microsc Res Tech. 2009; 72: 773-786
- Bisphenol a and reproductive health: update of experimental and human evidence, 2007–2013.Environ Health Perspect. 2014; 122: 775-786
- Perinatal exposure of rats to bisphenol A affects the fertility of male offspring.Life Sci. 2009; 85: 742-752
- Induction of mammary gland ductal hyperplasias and carcinoma in situ following fetal bisphenol A exposure.Reprod Toxicol. 2007; 23: 383-390
- Gestational and lactational exposure to ethinyl estradiol, but not bisphenol A, decreases androgen-dependent reproductive organ weights and epididymal sperm abundance in the male long evans hooded rat.Toxicol Sci. 2008; 102: 371-382
- Effects of in utero and lactational exposure to bisphenol A on somatic growth and anogenital distance in F1 rat offspring.Ind Health. 2002; 40: 375-381
- Three-generation reproductive toxicity study of dietary bisphenol A in CD Sprague-Dawley rats.Toxicol Sci. 2002; 68: 121-146
- Effects of in utero exposure to bisphenol A or diethylstilbestrol on the adult male reproductive system.Birth Defects Res B Dev Reprod Toxicol. 2011; 92: 526-533
- Effect of prenatal exposure to bisphenol A on the serum testosterone concentration of rats at birth.Hum Exp Toxicol. 2006; 25: 369-373
- In utero exposure to bisphenol-A and anogenital distance of male offspring.Birth Defects Res A Clin Mol Teratol. 2011; 91: 867-872
- The association between some endocrine disruptors and hypospadias in biological samples.J Environ Sci Health A Tox Hazard Subst Environ Eng. 2012; 47: 2173-2179
- Bisphenol A: an endocrine and metabolic disruptor.Ann Endocrinol (Paris). 2013; 74: 211-220
- Biology of insulin-like factor 3 in human reproduction.Hum Reprod Update. 2009; 15: 463-476
- Ontogenesis of the in vitro response of rat testis to gonadotropin-releasing hormone.Mol Cell Endocrinol. 1991; 82: 199-206
- Concerns about the widespread use of rodent models for human risk assessments of endocrine disruptors.Reproduction. 2014; 147: R119-R129
- Man is not a big rat: concerns with traditional human risk assessment of phthalates based on their antiandrogenic effects observed in the rat foetus.Basic Clin Androl. 2014; 24: 14
- Differential effects of bisphenol A and diethylstilbestrol on human, rat and mouse fetal Leydig cell function.PLoS One. 2012; 7: e51579
- Transforming growth factor beta1 and beta2 reduce the number of gonocytes by increasing apoptosis.Endocrinology. 1998; 139: 733-740
- Multiple effects of retinoids on the development of Sertoli, germ, and Leydig cells of fetal and neonatal rat testis in culture.Biol Reprod. 2000; 62: 1303-1314
- Endogenous estrogens inhibit mouse fetal Leydig cell development via estrogen receptor alpha.Endocrinology. 2005; 146: 2454-2461
- Organotypic culture, a powerful model for studying rat and mouse fetal testis development.Cell Tissue Res. 2006; 324: 507-521
- Use of organ culture to study the human fetal testis development: effect of retinoic acid.J Clin Endocrinol Metab. 2006; 91: 2696-2703
- A new method for toxicity assays on human and mouse fetal testis.Biochimie. 2006; 88: 1831-1835
- Developmental changes in testicular sensitivity to estrogens throughout fetal and neonatal life.Toxicol Sci. 2007; 99: 234-243
- Origin, differentiation and regulation of fetal and adult and adult Leydig Cells.Mol Cell Endocrinol. 2001; 179: 47-74
- Origin, development and regulation of human Leydig cells.Horm Res Paediatr. 2010; 73: 93-101
- Testosterone, dihydrotestosterone and estradiol-17 beta levels in maternal and fetal plasma and in fetal testes in the rat.J Steroid Biochem. 1984; 21: 193-198
- A sensitive bioassay for luteinizing hormone like activity applied to systemic plasma of fœtal rats.Acta Endocrinol (Copenh). 1981; 97: 176-180
- Control of testicular steroidogenesis in foetal rat: effect of decapitation on testosterone and plasma luteinizing hormone–like activity.Acta Endocrinol (Copenh). 1982; 99: 466-473
- Absence of detectable chorionic gonadotropin subunit messenger ribonucleic acids in the rat placenta throughout gestation.Endocrinology. 1985; 116: 1151-1157
- Expression of β subunit of chorionic gonadotropin in transgenic mice.J Biol Chem. 1994; 269: 4968-4973
- In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling.Hum Reprod. 2014; 29: 1471-1489
- Effect of decapitation and chronic in-vivo treatment with a gonadotrophin-releasing hormone agonist on testicular steroidogenesis in the rat fetus.J Endocrinol. 1992; 133: 245-251
- Luteinizing hormone-dependent activity and luteinizing hormone–independent differentiation of rat fetal Leydig cells.Mol Cell Endocrinol. 2001; 172: 193-202
- Phthalates impair germ cell number in the mouse fetal testis by an androgen- and estrogen-independent mechanism.Toxicol Sci. 2009; 111: 372-382
- In utero exposure to di-(2-ethylhexyl) phthalate exerts both short-term and long-lasting suppressive effects on testosterone production in the rat.Biol Reprod. 2008; 78: 1018-1028
- Developmental changes in in vitro testosterone production by dispersed Leydig cells during fetal life in rats.Arch Androl. 1991; 27: 65-71
Ben Maamar M, Lesné L, Desdoigts-Lethimonier C, Coiffec I, Lavoué V, Dejucq-Rainsford N, et al. Effect of bisphenol A on the rat and human fetal testis. In: 18th European Testis Workshop. Elsinore, Denmark, 2014.
- Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenic enzyme gene expression in rat Leydig cells.Endocrinology. 2004; 145: 592-603
- Effects of bisphenol s exposure on endocrine functions and reproduction of zebrafish.Environ Sci Technol. 2013; 47: 8793-8800
- In vitro study on the agonistic and antagonistic activities of bisphenol-S and other bisphenol-A congeners and derivatives via nuclear receptors.Toxicol Appl Pharmacol. 2013; 272: 127-136
- Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.Endocrinology. 1998; 139: 4252-4263
- Bisphenol A, an environmental endocrine-disrupting chemical, inhibits hypoxic response via degradation of hypoxia-inducible factor 1alpha (HIF-1alpha): structural requirement of bisphenol A for degradation of HIF-1alpha.Biochem Biophys Res Commun. 2004; 318: 1006-1011
- Comparative study of bisphenol A and its analogue bisphenol S on human hepatic cells: a focus on their potential involvement in nonalcoholic fatty liver disease.Food Chem Toxicol. 2014; 70: 9-18
- Bisphenol S disrupts estradiol-induced nongenomic signaling in a rat pituitary cell line: effects on cell functions.Environ Health Perspect. 2013; 121: 352-358
- Use of the gammaH2AX assay for assessing the genotoxicity of bisphenol A and bisphenol F in human cell lines.Arch Toxicol. 2011; 85: 1463-1473
- Is bisphenol S a safe substitute for bisphenol A in terms of metabolic function? An in vitro study.Toxicol Appl Pharmacol. 2014; 280: 224-235
- Bisphenol A downregulates Akt signaling and inhibits adiponectin production and secretion in 3T3-L1 adipocytes.J Atheroscler Thromb. 2010; 17: 834-843
- Are structural analogues to bisphenol a safe alternatives?.Toxicol Sci. 2014; 139: 35-47
- Bisphenol S, a new bisphenol analogue, in paper products and currency bills and its association with bisphenol a residues.Environ Sci Technol. 2012; 46: 6515-6522
- Concentrations and profiles of bisphenol A and other bisphenol analogues in foodstuffs from the United States and their implications for human exposure.J Agric Food Chem. 2013; 61: 4655-4662
- Bisphenol S in urine from the United States and seven Asian countries: occurrence and human exposures.Environ Sci Technol. 2012; 46: 6860-6866
- The industrial chemical bisphenol A (BPA) interferes with proliferative activity and development of steroidogenic capacity in rat Leydig cells.Biol Reprod. 2012; 86 (1–12): 135
- Effect of bisphenol A on human chorionic gonadotrophin–stimulated gene expression of cultured mouse Leydig tumour cells.Reprod Toxicol. 2007; 24: 265-275
- Bisphenol A disrupts steroidogenesis in human H295R cells.Toxicol Sci. 2011; 121: 320-327
S.E. has nothing to disclose. T.G. has nothing to disclose. D.M. has nothing to disclose. M.-J.G. has nothing to disclose. T.N’T.-B. has nothing to disclose. S.P.-G. has nothing to disclose. A.B. has nothing to disclose. G.L. has nothing to disclose. V.R.-F. has nothing to disclose. R.H. has nothing to disclose.
Supported by the University of Paris Diderot–Paris 7, the Atomic Energy Committee (CEA), the National Institute for Health and Medical Research (INSERM), the French Ministry of Ecology, Sustainable Development, Transports and Housing. (Program ANTIOPES–Storm), and the French National Agency for Safety in Food, Environment, and Work (ANSES; Environment and Health Program).
User LicenseCreative Commons Attribution - NonCommercial - NoDerivs |
For non-commercial purposes:
- Read, print & download
- Redistribute or republish the final article
- Text & data mine
- Translate the article
- Reuse portions or extracts from the article in other works (except for the author)
- Sell or re-use for commercial purposes
Elsevier's open access license policy