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Ovarian stimulation with Human Menopausal Gonadotropin (HMG) is more effective than Clomiphene Citrate (CC) in Intra-Uterine Insemination (IUI) using partner’s sperm, but not in IUI using donor frozen sperm

      Objective: To compare the effectiveness of hMG and CC on IUI outcome using donor frozen sperm or partner’s sperm.
      Design: A retrospective analysis of IUI results from January 2000 to March 2003.
      Materials and Methods: In 234 IUI cycles, women with infertility of various causes received either clomiphene citrate (CC) or hMG. Women stimulated with CC received 50–250 mg/day for 5 days starting on cycle day 3; and women stimulated with hMG were started on cycle day 3, if a baseline ultrasound revealed no ovarian cyst. When the largest follicle(s) reached a mean diameter of 19 mm, ovulation was induced with 10,000 IU hCG, and a single IUI was performed 36–38 hours later. Women underwent IUI using either their respective partners’ sperm or donor frozen sperm. Sperm specimens were washed by a gradient density method. Pregnancy was defined as ultrasonographic detection of a fetal heart beat(s). Pregnancy data were analyzed by least squares analysis of covariance using the General Linear Models Procedure of Statistical Analysis System (SAS), with medication type (CC, hMG) and type of sperm (Donor, Partner) as treatments in a 2 × 2 factorial design, and age of women as covariate.
      Results: Results are shown in the table.
      Tabled 1
      Table thumbnail GR61
      ∗a,b: P<0.05 within treatments; ∗∗ab: P≤0.05
      Conclusion: hMG results in higher pregnancy rate than CC in women inseminated with their partners’ sperm, but not in women inseminated with donor sperm. Insemination with donor or partner’s sperm results in similar pregnancy rates in CC-treated women as well as in hMG-treated women. The study is ongoing, and updated results will be presented at the meeting.