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Heritability of menopausal age in mothers and daughters

      Objective

      To determine the heritability of age at natural menopause from mother-daughter pairs.

      Design

      Two-generation families were selected to study heritability of menopausal age.

      Setting

      Subjects were drawn from a population-based study.

      Patient(s)

      One hundred sixty-four mother-daughter pairs with a natural menopausal age.

      Intervention(s)

      None.

      Main outcome measure(s)

      The heritability of age at natural menopause estimated by a random-effects model.

      Result(s)

      A heritability of 44% (95% confidence interval, 36%, 50%) was estimated.

      Conclusion(s)

      This study confirms that heritable components largely determine the natural age at menopause. Reasons for the differences between heritability estimates based on sibling pairs and parent-child comparisons are discussed.

      Key words

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