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Minimum number of sperm needed to obtain an intrauterine insemination pregnancy

      OBJECTIVE: Intrauterine insemination (IUI) with partner's sperm is a useful treatment for mild male factor, cervical factor infertility, as well as an adjunctive therapy among ovulation induction cycles. Previous studies washed the semen specimen with Sperm Wash Medium® (SWM) and resuspended the entire pellet (motile and nonmotile sperm) along with cellular debris in ∼ 0.2 to 0.4 mL of SWM. Patients that received these washed pellets collectively had a 10% pregnancy rate (PR). The possibility exists that contaminates from the nonmotile sperm and cellular debris may be deleterious to the motile spermatozoa, thus reducing the actual number of viable sperm that reach the ovulated oocyte. With the use of a gradient wash to separate the motile sperm from the detritus, is it possible to ascertain if there is a minimum number of motile sperm necessary to obtain a pregnancy? The objective of this study was to determine the relationship between sperm concentration and PR.
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