Progesterone supplementation during the luteal phase and in early pregnancy in the treatment of infertility: an educational bulletin

  • The Practice Committee of the American Society for Reproductive Medicine in collaboration with the Society for Reproductive Endocrinology and Infertility
      Exogenous progesterone supplementation is a common element of treatment regimens for infertility, particularly those relating to the assisted reproductive technologies.
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        • Csapo A.I.
        • Pulkkinen M.O.
        • Ruttner B.
        • Sauvage J.P.
        • Wiest W.G.
        The significance of the human corpus luteum in pregnancy maintenance. I. Preliminary studies.
        Am J Obstet Gynecol. 1972; 1128: 1061-1067
        • Csapo A.I.
        • Pulkkinen M.O.
        • Wiest W.G.
        Effects of luteectomy and progesterone replacement therapy in early pregnant patients.
        Am J Obstet Gynecol. 1973; 115: 759-765
        • Filicori M.
        • Butler J.P.
        • Crowley Jr., W.F.
        Neuroendocrine regulation of the corpus luteum in the human. Evidence for pulsatile progesterone secretion.
        J Clin Invest. 1984; 73: 1638-1647
        • Noyes R.W.
        • Hertig A.T.
        • Rock J.
        Dating the endometrial biopsy.
        Fertil Steril. 1950; 1: 3-25
        • Murray M.J.
        • Meyer W.R.
        • Zaino R.J.
        • Lessey B.A.
        • Novotny D.B.
        • Ireland K.
        • et al.
        A critical analysis of the accuracy, reproducibility, and clinical utility of histologic endometrial dating in fertile women.
        Fertil Steril. 2004; 81: 1333-1343
        • Coutifaris C.
        • Myers E.R.
        • Guzick D.S.
        • Diamond M.P.
        • Carson S.A.
        NICHD National Cooperative Reproductive Medicine Network, et al. Histological dating of timed endometrial biopsy tissue is not related to fertility status.
        Fertil Steril. 2004; 825: 1264-1272
        • Smitz J.
        • Erard P.
        • Camus M.
        • Devroey P.
        • Tournaye H.
        • Wisanto A.
        • et al.
        Pituitary gonadotrophin secretory capacity during the luteal phase in superovulation using GnRH-agonists and HMG in a desensitization or flare-up protocol.
        Hum Reprod. 1992; 7: 1225-1229
        • Smitz J.
        • Bourgain C.
        • Van Waesberghe L.
        • Camus M.
        • Devroey P.
        • Van Steirteghem A.C.
        A prospective randomized study on oestradiol valerate supplementation in addition to intravaginal micronized progesterone is buserelin and HMG-induced superovulation.
        Hum Reprod. 1993; 8: 40-45
        • Beckers N.G.
        • Macklon N.S.
        • Eijkemans M.J.
        • Ludwig M.
        • Felberbaum R.E.
        • Diedrich K.
        • et al.
        Nonsupplemented luteal phase characteristics after the administration of recombinant human chorionic gonadotropin, recombinant luteinizing hormone, or gonadotropin-releasing hormone (GnRH) agonist to induce final oocyte maturation in in vitro fertilization patients after ovarian stimulation with recombinant follicle-stimulating hormone and GnRH antagonist cotreatment.
        J Clin Endocrinol Metab. 2003; : 4186-4192
        • Tavaniotou A.
        • Devroey P.
        Luteal hormone profile of oocyte donors stimulated with a GnRH antagonist compared with natural cycles.
        Reprod Biomed Online. 2006; 13: 326-330
        • Pritts E.A.
        • Atwood A.K.
        Luteal phase support in infertility treatment: a meta-analysis of the randomized trials.
        Hum Reprod. 2002; 9: 2287-2299
        • Daya S.
        • Gunby J.
        Luteal phase support in assisted reproduction cycles.
        Cochrane Database Syst Rev. 2004; ([Review]) (CD004830)
        • Licciardi F.L.
        • Kwiatkowski A.
        • Noyes N.L.
        • Berkeley A.S.
        • Krey L.L.
        • Grifo J.A.
        Oral versus intramuscular progesterone for in vitro fertilization: a prospective randomized study.
        Fertil Steril. 1999; 71: 614-618
        • Friedler S.
        • Raziel A.
        • Schachter M.
        • Strassburger D.
        • Bukovsky I.
        • Ron-El R.
        Luteal support with micronized progesterone following in-vitro fertilization using a down-regulation protocol with gonadotrophin-releasing hormone agonist: a comparative study between vaginal and oral administration.
        Hum Reprod. 1999; 14: 1944-1948
        • Miles R.A.
        • Paulson R.J.
        • Lobo R.A.
        • Press M.F.
        • Dahmoush L.
        • Sauer M.V.
        Pharmacokinetics and endometrial tissue levels of progesterone after administration by intramuscular and vaginal routes: a comparative study.
        Fertil Steril. 1994; 62: 485-490
        • Perino M.
        • Brigandi F.G.
        • Abate F.G.
        • Costabile L.
        • Balzano E.
        • Abate A.
        Intramuscular versus vaginal progesterone in assisted reproduction: a comparative study.
        Clin Exp Obstet Gynecol. 1997; 24: 228-231
        • Propst A.M.
        • Hill J.A.
        • Ginsburg E.S.
        • Hurwitz S.
        • Politch J.
        • Yanushpolsky E.H.
        A randomized study comparing Crinone 8% and intramuscular progesterone supplementation in in vitro fertilization-embryo transfer cycles.
        Fertil Steril. 2001; 76: 1144-1149
        • Smitz J.
        • Devroey P.
        • Faguer B.
        • Bourgain C.
        • Camus M.
        • Van Steirteghem A.C.
        A prospective randomized comparison of intramuscular or intravaginal natural progesterone as a luteal phase and early pregnancy supplement.
        Hum Reprod. 1992; 7: 168-175
        • Carmichael S.L.
        • Shaw G.M.
        • Laurent C.
        • Croughan M.S.
        • Olney R.S.
        • Lammer E.J.
        Maternal progestin intake and risk of hypospadias.
        Arch Pediatr Adolesc Med. 2005; 159: 957-962
        • Ericson A.
        • Kallen B.
        Congenital malformations in infants born after IVF: a population-based study.
        Hum Reprod. 2001; 16: 504-509
        • William K.
        Hubbard, Acting Deputy Commissioner for Policy.
        Federal Register. April 13, 1999; 64 (Proposed Rules. FR Document 99–9146)