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Cleavage stage embryo biopsy significantly impairs embryonic reproductive potential while blastocyst biopsy does not: a novel paired analysis of cotransferred biopsied and non-biopsied sibling embryos

  • N.R. Treff
    Affiliations
    Reproductive Medicine Associates of New Jersey, Morristown, NJ; Obstetrics, Gynecology, and Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ; Genetics, Rutgers-The State University of New Jersey, Piscataway, NJ
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  • K.M. Ferry
    Affiliations
    Reproductive Medicine Associates of New Jersey, Morristown, NJ; Obstetrics, Gynecology, and Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ; Genetics, Rutgers-The State University of New Jersey, Piscataway, NJ
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  • T. Zhao
    Affiliations
    Reproductive Medicine Associates of New Jersey, Morristown, NJ; Obstetrics, Gynecology, and Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ; Genetics, Rutgers-The State University of New Jersey, Piscataway, NJ
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  • J. Su
    Affiliations
    Reproductive Medicine Associates of New Jersey, Morristown, NJ; Obstetrics, Gynecology, and Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ; Genetics, Rutgers-The State University of New Jersey, Piscataway, NJ
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  • E.J. Forman
    Affiliations
    Reproductive Medicine Associates of New Jersey, Morristown, NJ; Obstetrics, Gynecology, and Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ; Genetics, Rutgers-The State University of New Jersey, Piscataway, NJ
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  • R.T. Scott Jr.
    Affiliations
    Reproductive Medicine Associates of New Jersey, Morristown, NJ; Obstetrics, Gynecology, and Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ; Genetics, Rutgers-The State University of New Jersey, Piscataway, NJ
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      Recent advances in molecular genetics provide the opportunity to more accurately assess the reproductive potential of embryos. These technologies require embryonic DNA which necessitates embryo biopsy. Amongst the most critical questions surrounding these technologies are the risks associated with embryo biopsy itself, and whether biopsy is safest at the cleavage or blastocyst stage. This study uses a novel paired design to accurately assess the impact of biopsy on day 3 and day 5 of development.
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