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Comprehensive chromosome screening (CCS) results in significantly higher pregnancy rates and lower loss rates from single embryo transfer (SET) in a poor prognosis population

  • E.J. Forman
    Affiliations
    Reproductive Endocrinology & Infertility, Reproductive Medicine Associates of New Jersey, Morristown, NJ; Obstetrics, Gynecology and Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ; Genetics, Rutgers-The State University of New Jersey, Piscataway, NJ
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  • N.R. Treff
    Affiliations
    Reproductive Endocrinology & Infertility, Reproductive Medicine Associates of New Jersey, Morristown, NJ; Obstetrics, Gynecology and Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ; Genetics, Rutgers-The State University of New Jersey, Piscataway, NJ
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  • X. Tao
    Affiliations
    Reproductive Endocrinology & Infertility, Reproductive Medicine Associates of New Jersey, Morristown, NJ; Obstetrics, Gynecology and Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ; Genetics, Rutgers-The State University of New Jersey, Piscataway, NJ
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  • K.M. Ferry
    Affiliations
    Reproductive Endocrinology & Infertility, Reproductive Medicine Associates of New Jersey, Morristown, NJ; Obstetrics, Gynecology and Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ; Genetics, Rutgers-The State University of New Jersey, Piscataway, NJ
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  • D. Taylor
    Affiliations
    Reproductive Endocrinology & Infertility, Reproductive Medicine Associates of New Jersey, Morristown, NJ; Obstetrics, Gynecology and Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ; Genetics, Rutgers-The State University of New Jersey, Piscataway, NJ
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  • R.T. Scott
    Affiliations
    Reproductive Endocrinology & Infertility, Reproductive Medicine Associates of New Jersey, Morristown, NJ; Obstetrics, Gynecology and Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ; Genetics, Rutgers-The State University of New Jersey, Piscataway, NJ
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      Single embryo transfer provides the most certain means to reduce ART's principal complication – multiple gestation. Regrettably, every prospective trial comparing SET to multiple embryo transfer has demonstrated reductions in per cycle delivery rates. Central to SET's failure to attain equivalent outcomes is the inability to assess the reproductive potential of a given embryo. A recent randomized controlled trial demonstrated that CCS can dramatically increase implantation and delivery rates, suggesting that the use of CCS might improve SET outcomes. This study seeks to evaluate that question in an infertility population.
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