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Trophectoderm biopsy for single-gene disorder preimplantation genetic diagnosis (PGD) is significantly more reliable than day 3 blastomere biopsy

  • E.J. Forman
    Affiliations
    Reproductive Endocrinology & Infertility, Reproductive Medicine Associates of New Jersey, Morristown, NJ; Obstetrics, Gynecology and Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ; Fertility Laboratories of Colorado, Lone Tree, CO
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  • K.M. Ferry
    Affiliations
    Reproductive Endocrinology & Infertility, Reproductive Medicine Associates of New Jersey, Morristown, NJ; Obstetrics, Gynecology and Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ; Fertility Laboratories of Colorado, Lone Tree, CO
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  • N.-A. Gueye
    Affiliations
    Reproductive Endocrinology & Infertility, Reproductive Medicine Associates of New Jersey, Morristown, NJ; Obstetrics, Gynecology and Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ; Fertility Laboratories of Colorado, Lone Tree, CO
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  • R.D. Smith
    Affiliations
    Reproductive Endocrinology & Infertility, Reproductive Medicine Associates of New Jersey, Morristown, NJ; Obstetrics, Gynecology and Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ; Fertility Laboratories of Colorado, Lone Tree, CO
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  • J. Stevens
    Affiliations
    Reproductive Endocrinology & Infertility, Reproductive Medicine Associates of New Jersey, Morristown, NJ; Obstetrics, Gynecology and Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ; Fertility Laboratories of Colorado, Lone Tree, CO
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  • R.T. Scott Jr.
    Affiliations
    Reproductive Endocrinology & Infertility, Reproductive Medicine Associates of New Jersey, Morristown, NJ; Obstetrics, Gynecology and Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ; Fertility Laboratories of Colorado, Lone Tree, CO
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      The established paradigm for PGD of single-gene disorders (SGD) involves evaluation of a single cell biopsied from a cleavage-stage embryo. Strong evidence now indicates that this approach may be suboptimal with day 3 biopsy adversely impacting the reproductive potential of the embryo. Additionally, a substantial number of these biopsies do not provide interpretable results. While trophectoderm (TE) biopsy appears safe, the ability to reliably produce interpretable results remains unevaluated. This study seeks to compare the reliability with which interpretable PGD results are obtained following day 3 or TE biopsy.
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