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Inadequate luteinization: low serum progesterone after hCG trigger results in fewer mature oocytes per follicle and diminished pregnancy rates

  • K.H. Hong
    Affiliations
    Reproductive Endocrinology & Infertility, Reproductive Medicine Associates of New Jersey, Morristown, NJ; Obstetrics, Gynecology & Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ
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  • E.J. Forman
    Affiliations
    Reproductive Endocrinology & Infertility, Reproductive Medicine Associates of New Jersey, Morristown, NJ; Obstetrics, Gynecology & Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ
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  • A. Ruiz
    Affiliations
    Reproductive Endocrinology & Infertility, Reproductive Medicine Associates of New Jersey, Morristown, NJ; Obstetrics, Gynecology & Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ
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  • R.T. Scott Jr.
    Affiliations
    Reproductive Endocrinology & Infertility, Reproductive Medicine Associates of New Jersey, Morristown, NJ; Obstetrics, Gynecology & Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ
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      Follicular luteinization is a dynamic process that results in oocyte maturation and mucification of the cumulus-oocyte complex. Though controversial, premature luteinization – or inappropriate elevations of progesterone (P4) prior to surge levels of LH – may have a deleterious effect on IVF outcomes due to poor oocyte quality and/or impaired endometrial receptivity. The opposite case of inadequate luteinization (IL) – or inappropriately low P4 production – has received little attention in the ART literature. This study seeks to determine if varying degrees of P4 production in the period following mid-cycle hCG administration reflect altered follicular function and are predictive of changes in clinical outcomes.
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