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Spontaneous pregnancies among couples previously treated by in vitro fertilization

      Objective

      To determine the frequency of live births following spontaneous pregnancy (BSP) and to examine their associated factors among couples who have unsuccessfully or successfully experienced fertility treatments.

      Design

      Retrospective cohort.

      Setting

      Eight IVF centers.

      Patient(s)

      A total of 2,134 couples who began IVF treatment in the centers in 2000–2002 and were followed up by a postal questionnaire sent 7–9 years after they started treatment in the inclusion center.

      Intervention(s)

      None.

      Main Outcome Measure(s)

      Rates of BSP and factors associated with BSP. Univariate and multivariate analyses were conducted using logistic regression.

      Result(s)

      The BSP rate was 17% (218/1,320) among couples who had previously had a child through medical treatment and 24% (193/814) among couples who had remained childless after treatment. In both groups, the probability of BSP was higher among younger women and increased with a smaller number of IVF attempts. Probability was also higher when the cause of infertility was unexplained.

      Conclusion(s)

      Our results should give hope to couples who have been unsuccessfully treated by IVF, especially young couples with unexplained infertility. Nonetheless, it should be remembered that the BSP rates are cumulative rates observed over a long period of time and that these couples have a very low monthly probability of conceiving.

      Key Words

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      References

        • Hennelly B.
        • Harrison R.F.
        • Kelly J.
        • Jacob S.
        • Barrett T.
        Spontaneous conception after a successful attempt at in vitro fertilization/intracytoplasmic sperm injection.
        Fertil Steril. 2000; 73: 774-778
        • Ludwig A.K.
        • Katalinic A.
        • Jendrysik J.
        • Thyen U.
        • Sutcliffe A.G.
        • Diedrich K.
        • et al.
        Spontaneous pregnancy after successful ICSI treatment: evaluation of risk factors in 899 families in Germany.
        Reprod Biomed Online. 2008; 17: 403-409
        • Brandes M.
        • van der Steen J.O.
        • Bokdam S.B.
        • Hamilton C.J.
        • de Bruin J.P.
        • Nelen W.L.
        • et al.
        When and why do subfertile couples discontinue their fertility care? A longitudinal cohort study in a secondary care subfertility population.
        Hum Reprod. 2009; 24: 3127-3135
        • Horne G.
        • Farrell C.
        • Pease E.H.
        • Brison D.R.
        • Falconer D.A.
        • Lieberman B.A.
        Waiting for in vitro fertilization treatment: spontaneous and ART live births.
        Hum Fertil (Camb). 2003; 6: 116-121
        • van Dongen A.J.
        • Verhagen T.E.
        • Dumoulin J.C.
        • Land J.A.
        • Evers J.L.
        Reasons for dropping out from a waiting list for in vitro fertilization.
        Fertil Steril. 2009; 94: 1713-1716
        • Shimizu Y.
        • Kodama H.
        • Fukuda J.
        • Murata M.
        • Kumagai J.
        • Tanaka T.
        Spontaneous conception after the birth of infants conceived through in vitro fertilization treatment.
        Fertil Steril. 1999; 71: 35-39
        • Pinborg A.
        • Hougaard C.O.
        • Nyboe Andersen A.
        • Molbo D.
        • Schmidt L.
        Prospective longitudinal cohort study on cumulative 5-year delivery and adoption rates among 1338 couples initiating infertility treatment.
        Hum Reprod. 2009; 24: 991-999
        • Osmanagaoglu K.
        • Collins J.
        • Kolibianakis E.
        • Tournaye H.
        • Camus M.
        • Van Steirteghem A.
        • et al.
        Spontaneous pregnancies in couples who discontinued intracytoplasmic sperm injection treatment: a 5-year follow-up study.
        Fertil Steril. 2002; 78: 550-556
        • Cahill D.J.
        • Meadowcroft J.
        • Akande V.A.
        • Corrigan E.
        Likelihood of natural conception following treatment by IVF.
        J Assist Reprod Genet. 2005; 22: 401-405
        • Filetto J.N.
        • Makuch M.Y.
        Long-term follow-up of women and men after unsuccessful IVF.
        Reprod Biomed Online. 2005; 11: 458-463
        • de La Rochebrochard E.
        • Quelen C.
        • Peikrishvili R.
        • Guibert J.
        • Bouyer J.
        Long-term outcome of parenthood project during in vitro fertilization and after discontinuation of unsuccessful in vitro fertilization.
        Fertil Steril. 2009; 92: 149-156
        • Osmanagaoglu K.
        • Tournaye H.
        • Camus M.
        • Vandervorst M.
        • van Steirteghem A.
        • Devroey P.
        Cumulative delivery rates after intracytoplasmic sperm injection: 5 year follow-up of 498 patients.
        Hum Reprod. 1999; 14: 2651-2655
        • Brandes M.
        • Hamilton C.J.
        • de Bruin J.P.
        • Nelen W.L.
        • Kremer J.A.
        The relative contribution of IVF to the total ongoing pregnancy rate in a subfertile cohort.
        Hum Reprod. 2010; 25: 118-126
        • Eijkemans M.J.
        • Lintsen A.M.
        • Hunault C.C.
        • Bouwmans C.A.
        • Hakkaart L.
        • Braat D.D.
        • et al.
        Pregnancy chances on an IVF/ICSI waiting list: a national prospective cohort study.
        Hum Reprod. 2008; 23: 1627-1632
        • Kupka M.S.
        • Dorn C.
        • Richter O.
        • Schmutzler A.
        • van der Ven H.
        • Kulczycki A.
        Stress relief after infertility treatment—spontaneous conception, adoption and psychological counselling.
        Eur J Obstet Gynecol Reprod Biol. 2003; 110: 190-195
        • Vardon D.
        • Burban C.
        • Collomb J.
        • Stolla V.
        • Erny R.
        [Spontaneous pregnancies in couples after failed or successful in vitro fertilization].
        J Gynecol Obstet Biol Reprod. 1995; 24 ([French.]): 811-815
        • Brandes M.
        • Hamilton C.J.
        • van der Steen J.O.
        • de Bruin J.P.
        • Bots R.S.
        • Nelen W.L.
        • et al.
        Unexplained infertility: overall ongoing pregnancy rate and mode of conception.
        Hum Reprod. 2011; 26: 360-368
        • Spira A.
        Epidemiology of human reproduction.
        Hum Reprod. 1986; 1: 111-115