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Blastocyst euploid selective transfer (BEST): an RCT of comprehensive chromosome screening-single embryo transfer (CCS-SET) vs double embryo transfer (DET)-equivalent pregnancy rates, eliminates twins

  • E.J. Forman
    Affiliations
    Reproductive Endocrinology, Reproductive Medicine Associates of New Jersey, Morristown, NJ

    Obstetrics, Gynecology & Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ
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  • K.H. Hong
    Affiliations
    Reproductive Endocrinology, Reproductive Medicine Associates of New Jersey, Morristown, NJ

    Obstetrics, Gynecology & Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ
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  • K.M. Ferry
    Affiliations
    Reproductive Endocrinology, Reproductive Medicine Associates of New Jersey, Morristown, NJ

    Obstetrics, Gynecology & Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ
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  • X. Tao
    Affiliations
    Reproductive Endocrinology, Reproductive Medicine Associates of New Jersey, Morristown, NJ
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  • N.R. Treff
    Affiliations
    Reproductive Endocrinology, Reproductive Medicine Associates of New Jersey, Morristown, NJ

    Obstetrics, Gynecology & Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ

    Genetics, Rutgers-The State University of New Jersey, Piscataway, NJ
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  • R.T. Scott Jr.
    Affiliations
    Reproductive Endocrinology, Reproductive Medicine Associates of New Jersey, Morristown, NJ

    Obstetrics, Gynecology & Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ
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      The goal of ART is to optimize delivery rates and minimize adverse outcomes. To that end, SET has been advocated to eliminate ART's main complication – multiple gestation. All RCTs comparing SET to DET demonstrate inferior per-cycle delivery rates due to a limited ability to predict a given embryo's reproductive potential. The difference in outcomes might be reduced by using chromosome screening to enhance selection of the best embryo and achieving higher implantation rates. This study seeks to determine if CCS-SET can attain equivalent outcomes to morphology-based DET while minimizing multiple gestation.
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