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Development of a novel next-gen sequencing (NGS) methodology for accurate characterization of genome-wide mitochondrial heteroplasmy in human embryos

  • K.H. Hong
    Affiliations
    Reproductive Endocrinology, Reproductive Medicine Associates of New Jersey, Morristown, NJ

    Obstetrics, Gynecology & Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ
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  • D.M. Taylor
    Affiliations
    Reproductive Endocrinology, Reproductive Medicine Associates of New Jersey, Morristown, NJ

    Obstetrics, Gynecology & Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ
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  • E. Forman
    Affiliations
    Reproductive Endocrinology, Reproductive Medicine Associates of New Jersey, Morristown, NJ
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  • X. Tao
    Affiliations
    Reproductive Endocrinology, Reproductive Medicine Associates of New Jersey, Morristown, NJ
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  • N.R. Treff
    Affiliations
    Reproductive Endocrinology, Reproductive Medicine Associates of New Jersey, Morristown, NJ

    Obstetrics, Gynecology & Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ

    Genetics, Rutgers-The State University of New Jersey, Piscataway, NJ
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  • R. Scott
    Affiliations
    Reproductive Endocrinology, Reproductive Medicine Associates of New Jersey, Morristown, NJ
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      Although it is known that mitochondria play a critical role in embryogenesis, the ability to characterize the sequence integrity of the entire mitochondrial genome in an embryo has yet to be developed. This study seeks to establish a novel NGS based methodology to characterize the entire mitochondrial genome sequence in human embryos for the first time.
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