Embryos whose polar bodies had a reciprocal chromosomal abnormality are almost always euploid: a result of correction of premature separation of sister chromatids (PSSC)

      Polar body (PB) based aneuploidy screening has been advocated as a less invasive method for evaluating maternal meiotic errors. Given that errors occur in meiosis I and II (MI and MII), both PBs are typically screened. Interpreting PB screening results is not simple. In some cases, PB1 and PB2 have reciprocal errors – a gain in a given chromosome in PB1 followed by its loss in PB2 or vice versa. If non-disjunction (ND) occurred, reciprocal PB errors would result in an aneuploid embryo. When PSSC occurs, reciprocal errors actually predict embryonic euploidy with the ability to produce healthy infants. This study details how often oocytes with reciprocal PB errors result in euploid embryos in order to develop an evidence-based approach to the clinical management of PB-based screening results.
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