Oocyte vitrification does not result in a decrement in mitochondrial DNA (mtDNA) copy number in resulting embryos: a paired randomized controlled trial (RCT)

      It has previously been shown in a paired RCT that although the implantation rate after blastocyst transfer and the aneuploidy rate of the entire cohort of embryos are equivalent after oocyte vitrification, overall in vitro development is less efficient with a higher proportion of embryos arresting prior to transfer. This suggests that the developmental impact of vitrification may be related to a non-chromosomal effect. As mitochondria are extremely active in embryogenesis, this study seeks to determine whether oocyte vitrification has an impact on mtDNA copy number in the resulting embryo.
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