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Optimizing the temperature for embryo culture in IVF: a randomized controlled trial (RCT) comparing standard culture temperature of 37C to the reduced more physiologic temperature of 36C

      In most modern IVF laboratories, human oocytes and embryos are cultured at 37C - human core temperature. While intuitive, the ideal temperature for in vitro embryo culture has not been determined. In fact, studies in animal models and humans suggest that ovarian follicles and fallopian tubes are typically at least 1C cooler than core. According to Leese's “Quiet Embryo Hypothesis”, preimplantation embryos may develop optimally at a less stressful reduced metabolic rate resulting from cooler in vivo temperatures. This study seeks to determine whether in vitro culture at 36C results in improved blastulation and ultimately implantation.
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