Advertisement

Quo vadis randomized controlled trials in infertility?

      In this issue of Fertility and Sterility, the article by Glujovsky et al. (

      Glujovsky M, Riestra B, Coscia A, C. B, Comande D, Ciapponi A. Assessment of research quality in major infertility journals. Fertil Steril 2012;98:1539–43.

      ) on the methodologic quality of infertility randomized controlled trials (RCTs) (and systematic reviews) gives us pause to reflect: do we stay our present course or return to Rome to fight for our cause? These authors have reviewed the quality of randomized controlled trials over a 6-year period, 2006–2011, in the five leading journals in human reproduction, according to impact factor (Fertility and Sterility, Human Reproduction, Human Reproduction Update, Reproductive BioMedicine Online, and Reproduction). They report summary data that are both reassuring and disconcerting regarding the conduct of RCTs in infertility.
      To read this article in full you will need to make a payment

      References

      1. Glujovsky M, Riestra B, Coscia A, C. B, Comande D, Ciapponi A. Assessment of research quality in major infertility journals. Fertil Steril 2012;98:1539–43.

        • DeAngelis C.D.
        • Drazen J.M.
        • Frizelle F.A.
        • Haug C.
        • Hoey J.
        • Horton R.
        • et al.
        Clinical trial registration: a statement from the International Committee of Medical Journal Editors.
        JAMA. 2004; 292: 1363-1364
        • Schulz K.F.
        • Chalmers I.
        • Grimes D.A.
        • Altman D.G.
        Assessing the quality of randomization from reports of controlled trials published in obstetrics and gynecology journals.
        JAMA. 1994; 272: 125-128
        • Schulz K.F.
        • Grimes D.A.
        Allocation concealment in randomised trials: defending against deciphering.
        Lancet. 2002; 359: 614-618
        • Dapuzzo L.
        • Seitz F.E.
        • Dodson W.C.
        • Stetter C.
        • Kunselman A.R.
        • Legro R.S.
        Incomplete and inconsistent reporting of maternal and fetal outcomes in infertility treatment trials.
        Fertil Steril. 2011; 95: 2527-2530

      Linked Article