Accrual of euploid blastocysts after comprehensive chromosome screening (CCS) is a novel strategy to improve transfer outcomes and set expectations in poor prognosis patients

      Poor responders have lower per ET delivery rates and higher miscarriage rates than normal responders, perhaps resulting in discontinuation of care. Extensive validation of CCS has demonstrated improved sustained implantation rates (SIR) of euploid embryos, but have principally focused on normal responders. Whether the benefit applies to patients at high risk of poor outcomes has not been evaluated. This study seeks to evaluate IVF success rates in poor prognosis patients using a strategy of extended culture, trophectoderm (TE) biopsy for CCS, vitrification and frozen ET (FET) of euploid blastocysts.
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