SNP array intensity analysis of the 1st polar body (PB1) can reliably identify premature separation of sister chromatids (PSSC) in meiosis I (MI): a blinded validation study

      PSSC is the predominant mechanism of MI errors contributing to the age-related increase in aneuploidy. Distinguishing PSSC from non-disjunction (ND) is important but requires sequential PB and embryo biopsy. Embryos resulting from oocytes with reciprocal errors of the same chromosome in PB1 and PB2 will be euploid following PSSC but aneuploid after ND. This creates clinical uncertainty and hampers research into the mechanisms of MI errors. This study seeks to determine whether signal intensity analysis from PB1 SNP arrays can predict the nature of MI errors.
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