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Targeted deep sequencing of maternal cohesin genes as putative biomarkers for increased risk of embryonic aneuploidy

      The cohesin complex is a family of proteins that maintains chromatid cohesion and regulates chromosome segregation during cell division. Since premature separation of sister chromatids (PSSC) accounts for >90% of meiosis I (MI) errors, it is plausible that cohesin abnormalities may confer an increased risk for embryonic aneuploidy. This study uses a combination of oocyte genome-wide gene expression analysis and targeted maternal next generation sequencing (NGS) to investigate if sequence variations in specific cohesin pathway genes are associated with elevated or reduced risks for MI errors.
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