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Semen quality in relation to antioxidant intake in a healthy male population

      Objective

      To assess the relationship between dietary antioxidant intake and semen quality in young healthy males.

      Design

      Cross-sectional study.

      Setting

      University and college campuses in the Rochester, New York, area.

      Patient(s)

      One hundred eighty-nine university-aged men.

      Intervention(s)

      None.

      Main Outcome Measure(s)

      Semen volume, total sperm count, concentration, motility, total motile count, and morphology.

      Result(s)

      Progressive motility was 6.5 (95% confidence interval [CI], 0.6, 12.3) percentage units higher among men in the highest quartile of β-carotene intake compared with men in the lowest quartile. Similar results were observed for lutein intake. Lycopene intake was positively related to sperm morphology. The adjusted percentages (95% CI) of morphologically normal sperm in increasing quartiles of lycopene intake were 8.0 (6.7, 9.3), 7.7 (6.4, 9.0), 9.2 (7.9, 10.5), and 9.7 (8.4, 11.0). There was a nonlinear relationship between vitamin C intake and sperm concentration, with men in the second quartile of intake having, on average, the highest sperm concentrations and men in the top quartile of intake having the lowest concentrations.

      Conclusion(s)

      In a population of healthy young men, carotenoid intake was associated with higher sperm motility and, in the case of lycopene, better sperm morphology. Our data suggest that dietary carotenoids may have a positive impact on semen quality.

      Key Words

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      References

        • Agarwal A.
        • Sharma R.K.
        • Nallella K.P.
        • Thomas Jr., A.J.
        • Alvarez J.G.
        • Sikka S.C.
        Reactive oxygen species as an independent marker of male factor infertility.
        Fertil Steril. 2006; 86: 878-885
        • Kao S.H.
        • Chao H.T.
        • Chen H.W.
        • Hwang T.I.
        • Liao T.L.
        • Wei Y.H.
        Increase of oxidative stress in human sperm with lower motility.
        Fertil Steril. 2008; 89: 1183-1190
        • Gharagozloo P.
        • Aitken R.J.
        The role of sperm oxidative stress in male infertility and the significance of oral antioxidant therapy.
        Hum Reprod. 2011; 26: 1628-1640
        • MacLeod J.
        The role of oxygen in the metabolism and motility of human spermatozoa.
        Am J Physiol. 1943; 138: 512-518
        • Lewis S.E.
        • Boyle P.M.
        • McKinney K.A.
        • Young I.S.
        • Thompson W.
        Total antioxidant capacity of seminal plasma is different in fertile and infertile men.
        Fertil Steril. 1995; 64: 868-870
        • Sharma R.K.
        • Pasqualotto F.F.
        • Nelson D.R.
        • Thomas Jr., A.J.
        • Agarwal A.
        The reactive oxygen species-total antioxidant capacity score is a new measure of oxidative stress to predict male infertility.
        Hum Reprod. 1999; 14: 2801-2807
        • Pasqualotto F.F.
        • Sharma R.K.
        • Nelson D.R.
        • Thomas A.J.
        • Agarwal A.
        Relationship between oxidative stress, semen characteristics, and clinical diagnosis in men undergoing infertility investigation.
        Fertil Steril. 2000; 73: 459-464
        • Shiva M.
        • Gautam A.K.
        • Verma Y.
        • Shivgotra V.
        • Doshi H.
        • Kumar S.
        Association between sperm quality, oxidative stress, and seminal antioxidant activity.
        Clin Biochem. 2011; 44: 319-324
        • Suleiman S.A.
        • Ali M.E.
        • Zaki Z.M.
        • el-Malik E.M.
        • Nasr M.A.
        Lipid peroxidation and human sperm motility: protective role of vitamin E.
        J Androl. 1996; 17: 530-537
        • Scott R.
        • MacPherson A.
        • Yates R.W.
        • Hussain B.
        • Dixon J.
        The effect of oral selenium supplementation on human sperm motility.
        Br J Urol. 1998; 82: 76-80
        • Rolf C.
        • Cooper T.G.
        • Yeung C.H.
        • Nieschlag E.
        Antioxidant treatment of patients with asthenozoospermia or moderate oligoasthenozoospermia with high-dose vitamin C and vitamin E: a randomized, placebo-controlled, double-blind study.
        Hum Reprod. 1999; 14: 1028-1033
        • Keskes-Ammar L.
        • Feki-Chakroun N.
        • Rebai T.
        • Sahnoun Z.
        • Ghozzi H.
        • Hammami S.
        • et al.
        Sperm oxidative stress and the effect of an oral vitamin E and selenium supplement on semen quality in infertile men.
        Arch Androl. 2003; 49: 83
        • Greco E.
        • Iacobelli M.
        • Rienzi L.
        • Ubaldi F.
        • Ferrero S.
        • Tesarik J.
        Reduction of the incidence of sperm DNA fragmentation by oral antioxidant treatment.
        J Androl. 2005; 26: 349-353
        • Omu A.E.
        • Al-Azemi M.K.
        • Kehinde E.O.
        • Anim J.T.
        • Oriowo M.A.
        • Mathew T.C.
        Indications of the mechanisms involved in improved sperm parameters by zinc therapy.
        Med Princ Pract. 2008; 17: 108-116
        • Tarin J.J.
        • Brines J.
        • Cano A.
        Antioxidants may protect against infertility.
        Hum Reprod. 1998; 13: 1415-1416
        • Menezo Y.J.
        • Hazout A.
        • Panteix G.
        • Robert F.
        • Rollet J.
        • Cohen-Bacrie P.
        • et al.
        Antioxidants to reduce sperm DNA fragmentation: an unexpected adverse effect.
        Reprod Biomed Online. 2007; 14: 418-421
        • Murata M.
        • Kawanishi S.
        Oxidative DNA damage by vitamin A and its derivative via superoxide generation.
        J Biol Chem. 2000; 275: 2003-2008
        • Silver E.W.
        • Eskenazi B.
        • Evenson D.P.
        • Block G.
        • Young S.
        • Wyrobek A.J.
        Effect of antioxidant intake on sperm chromatin stability in healthy nonsmoking men.
        J Androl. 2005; 26: 550-556
        • Eskenazi B.
        • Kidd S.A.
        • Marks A.R.
        • Sloter E.
        • Block G.
        • Wyrobek A.J.
        Antioxidant intake is associated with semen quality in healthy men.
        Hum Reprod. 2005; 20: 1006-1012
        • Mínguez-Alarcón L.
        • Mediola J.
        • López-Espín J.J.
        • Sarabia-Cos L.
        • Vivero-Salmerón G.
        • Vioque J.
        • et al.
        Dietary intake of antioxidant nutrients is associated with semen quality in young university students.
        Hum Reprod. 2012; 27: 2807-2814
        • Mendiola J.
        • Torres-Cantero A.M.
        • Vioque J.
        • Moreno-Grau J.M.
        • Ten J.
        • Roca M.
        • et al.
        A low intake of antioxidant nutrients is associated with poor semen quality in patients attending fertility clinics.
        Fertil Steril. 2010; 93: 1128-1133
        • Menkveld R.
        • Stander F.S.
        • Kotze T.J.
        • Kruger T.F.
        • van Zyl J.A.
        The evaluation of morphological characteristics of human spermatozoa according to stricter criteria.
        Hum Reprod. 1990; 5: 586-592
        • Rimm E.B.
        • Giovannucci E.L.
        • Stampfer M.J.
        • Colditz G.A.
        • Litin L.B.
        • Willett W.C.
        Reproducibility and validity of an expanded self-administered semiquantitative food frequency questionnaire among male health professionals.
        Am J Epidemiol. 1992; 135 (discussion 27–36): 1114-1126
        • Willett W.C.
        • Howe G.R.
        • Kushi L.H.
        Adjustment for total energy intake in epidemiologic studies.
        Am J Clin Nutr. 1997; 65 (discussion 9S–31S): 1220S-1228S
        • Rothman K.J.
        • Greenland S.
        • Lash T.L.
        Modern epidemiology.
        3d ed. Lippincott Williams & Wilkins, Philadelphia, PA2008
        • Schisterman E.F.
        • Cole S.R.
        • Platt R.W.
        Overadjustment bias and unnecessary adjustment in epidemiologic studies.
        Epidemiology. 2009; 20: 488-495
        • Searle S.R.
        • Speed F.M.
        • Milliken G.A.
        Population marginal means in the linear model: an alternative to least square means.
        Am Stat. 1980; 34: 215-221
        • Ross C.
        • Morriss A.
        • Khairy M.
        • Khalaf Y.
        • Braude P.
        • Coomarasamy A.
        • et al.
        A systematic review of the effect of oral antioxidants on male infertility.
        Reprod Biomed Online. 2010; 20: 711-723
        • Gupta N.P.
        • Kumar R.
        Lycopene therapy in idiopathic male infertility—a preliminary report.
        Int Urol Nephrol. 2002; 34: 369-372
        • Otten J.
        • Pitzi Hellwig J.
        • Meyers L.
        Carotenoids.
        in: Otten J. Pitzi Hellwig J. Meyers L. Dietary reference intakes: The essential guide to nutrient requirements. National Academies Press, Washington, D.C.2006: 211-218
        • Dawson E.B.
        • Harris W.A.
        • Teter M.C.
        • Powell L.C.
        Effect of ascorbic acid supplementation on the sperm quality of smokers.
        Fertil Steril. 1992; 58: 1034-1039
        • Dawson E.B.
        • Harris W.A.
        • Rankin W.E.
        • Charpentier L.A.
        • McGanity W.J.
        Effect of ascorbic acid on male fertility.
        Ann N Y Acad Sci. 1987; 498: 312-323
        • Stokes-Riner A.
        • Thurston S.W.
        • Brazil C.
        • Guzick D.
        • Liu F.
        • Overstreet J.W.
        • et al.
        One semen sample or 2? Insights from a study of fertile men.
        J Androl. 2007; 28: 638-643