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Female dietary antioxidant intake and time to pregnancy among couples treated for unexplained infertility

      Objective

      To determine whether increased antioxidant intake in women is associated with shorter time to pregnancy (TTP) among a cohort of couples being treated for unexplained infertility.

      Design

      Secondary data analysis of a randomized controlled trial.

      Setting

      Academic medical center associated with a private infertility center.

      Patients

      Females with unexplained infertility.

      Interventions

      None.

      Main Outcome Measure(s)

      The time it took to establish a pregnancy that led to a live birth.

      Result(s)

      Mean nutrient intake exceeded the estimated average requirement (EAR) for vitamins C and E. No differences in mean intake of any of the antioxidants were noted between women who delivered a live-born infant during the study period vs. those who did not. In multivariable models, intake of β-carotene from dietary supplements was associated with shorter TTP among women with body mass index (BMI) ≥25 kg/m2 (hazard ratio [HR] 1.29, 95% confidence interval [CI] 1.09–1.53) and women <35 y (HR 1.19, 95% CI 1.01–1.41). Intake of vitamin C from dietary supplements was associated with shorter TTP among women with BMI <25 kg/m2 (HR 1.09, 95% CI 1.03–1.15) and women <35 y (HR 1.10, 95% CI 1.02–1.18). Intake of vitamin E from dietary supplements among women ≥35 y also was associated with shorter TTP (HR 1.07, 95% CI 1.01–1.13).

      Conclusion(s)

      Shorter TTP was observed among women with BMI <25 kg/m2 with increasing vitamin C, women with BMI ≥25 kg/m2 with increasing β-carotene, women <35 y with increasing β-carotene and vitamin C, and women ≥35 y with increasing vitamin E.

      Clinical Trial Registration Number

      Key Words

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      References

        • Ruder E.H.
        • Hartman T.J.
        • Blumberg J.
        • Goldman M.B.
        Oxidative stress and antioxidants: exposure and impact on female fertility.
        Hum Reprod Update. 2008; 14: 345-357
        • Polak G.
        • Koziol-Montewka M.
        • Gogacz M.
        • Blaszkowska I.
        • Kotarski J.
        Total antioxidant status of peritoneal fluid in infertile women.
        Eur J Obstet Gynecol Reprod Biol. 2001; 94: 261-263
        • Fenkci V.
        • Fenkci S.
        • Yilmazer M.
        • Serteser M.
        Decreased total antioxidant status and increased oxidative stress in women with polycystic ovary syndrome may contribute to the risk of cardiovascular disease.
        Fertil Steril. 2003; 80: 123-127
        • Bolumar F.
        • Olsen J.
        • Rebagliato M.
        • Saez-Lloret I.
        • Bisanti L.
        Body mass index and delayed conception: a European multicenter study on infertility and subfecundity.
        Am J Epidemiol. 2000; 151: 1072-1079
        • Brown L.A.
        • Kerr C.J.
        • Whiting P.
        • Finer N.
        • McEneny J.
        • Ashton T.
        Oxidant stress in healthy normal-weight, overweight, and obese individuals.
        Obesity (Silver Spring). 2009; 17: 460-466
        • Tatone C.
        • Amicarelli F.
        • Carbone M.C.
        • Monteleone P.
        • Caserta D.
        • Marci R.
        • et al.
        Cellular and molecular aspects of ovarian follicle ageing.
        Hum Reprod Update. 2008; 14: 131-142
        • Food and Nutrition Board
        Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids.
        National Academies Press, Washington, DC2003
        • Chavarro J.E.
        • Rich-Edwards J.W.
        • Rosner B.A.
        • Willett W.C.
        Diet and lifestyle in the prevention of ovulatory disorder infertility.
        Obstet Gynecol. 2007; 110: 1050-1058
        • Crosignani P.G.
        • Colombo M.
        • Vegetti W.
        • Somigliana E.
        • Gessati A.
        • Ragni G.
        Overweight and obese anovulatory patients with polycystic ovaries: parallel improvements in anthropometric indices, ovarian physiology and fertility rate induced by diet.
        Hum Reprod. 2003; 18: 1928-1932
        • Hjollund N.H.
        • Jensen T.K.
        • Bonde J.P.
        • Henriksen T.B.
        • Andersson A.M.
        • Skakkebaek N.E.
        Is glycosylated haemoglobin a marker of fertility? A follow-up study of first-pregnancy planners.
        Hum Reprod. 1999; 14: 1478-1482
        • Twigt J.M.
        • Bolhuis M.E.
        • Steegers E.A.
        • Hammiche F.
        • van Inzen W.G.
        • Laven J.S.
        • et al.
        The preconception diet is associated with the chance of ongoing pregnancy in women undergoing IVF/ICSI treatment.
        Hum Reprod. 2012; 27: 2526-2531
        • Ervin R.B.
        • Wright J.D.
        • Wang C.Y.
        • Kennedy-Stephenson J.
        Dietary intake of selected vitamins for the United States Population: 1999-2000. Advance data from vital health statistics; no 339.
        National Center for Health Statistics, Hyattsville, Maryland2004
        • Howarth N.C.
        • Huang T.T.
        • Roberts S.B.
        • Lin B.H.
        • McCrory M.A.
        Eating patterns and dietary composition in relation to BMI in younger and older adults.
        Int J Obes (Lond). 2007; 31: 675-684
        • Reindollar R.H.
        • Regan M.M.
        • Neumann P.J.
        • Levine B.S.
        • Thornton K.L.
        • Alper M.M.
        • et al.
        A randomized clinical trial to evaluate optimal treatment for unexplained infertility: the fast track and standard treatment (FASTT) trial.
        Fertil Steril. 2010; 94: 888-899
        • Block G.
        • Woods M.
        • Potosky A.
        • Clifford C.
        Validation of a self-administered diet history questionnaire using multiple diet records.
        J Clin Epidemiol. 1990; 43: 1327-1335
        • Willett W.
        • Stampfer M.J.
        Total energy intake: implications for epidemiologic analyses.
        Am J Epidemiol. 1986; 124: 17-27
        • Woodall A.A.
        • Ames B.
        Nutritional prevention of DNA damage to sperm and consequent risk reduction in birth defects and cancer in offspring.
        in: Bendich A. Preventive nutrition: the comprehensive guide for health professionals. Humana Press, Totowa, NJ1997: 373-385
        • Sharma R.K.
        • Agarwal A.
        Role of reactive oxygen species in male infertility.
        Urology. 1996; 48: 835-850
        • Sneed M.L.
        • Uhler M.L.
        • Grotjan H.E.
        • Rapisarda J.J.
        • Lederer K.J.
        • Beltsos A.N.
        Body mass index: impact on IVF success appears age-related.
        Hum Reprod. 2008; 23: 1835-1839
        • van Loendersloot L.L.
        • van Wely M.
        • Limpens J.
        • Bossuyt P.M.
        • Repping S.
        • van der Veen F.
        Predictive factors in in vitro fertilization (IVF): a systematic review and meta-analysis.
        Hum Reprod Update. 2010; 16: 577-589
        • Ervin R.B.
        • Wright J.D.
        • Wang C.Y.
        • Kennedy-Stephenson J.
        Dietary intake of selected vitamins for the United States population: 1999–2000.
        Adv Data. 2004; : 1-4
        • Chan A.C.
        Partners in defense, vitamin E and vitamin C.
        Can J Physiol Pharmacol. 1993; 71: 725-731
        • Luck M.R.
        • Zhao Y.
        Identification and measurement of collagen in the bovine corpus luteum and its relationship with ascorbic acid and tissue development.
        J Reprod Fertil. 1993; 99: 647-652
        • Davi G.
        • Guagnano M.T.
        • Ciabattoni G.
        • Basili S.
        • Falco A.
        • Marinopiccoli M.
        • et al.
        Platelet activation in obese women: role of inflammation and oxidant stress.
        J Am Med Assoc. 2002; 288: 2008-2014
        • Lashen H.
        • Fear K.
        • Sturdee D.W.
        Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case-control study.
        Hum Reprod. 2004; 19: 1644-1646
        • Bellver J.
        • Rossal L.P.
        • Bosch E.
        • Zuniga A.
        • Corona J.T.
        • Melendez F.
        • et al.
        Obesity and the risk of spontaneous abortion after oocyte donation.
        Fertil Steril. 2003; 79: 1136-1140
        • Wang J.X.
        • Davies M.J.
        • Norman R.J.
        Obesity increases the risk of spontaneous abortion during infertility treatment.
        Obes Res. 2002; 10: 551-554
        • Tiboni G.M.
        • Bucciarelli T.
        • Giampietro F.
        • Sulpizio M.
        • Di Ilio C.
        Influence of cigarette smoking on vitamin E, vitamin A, beta-carotene and lycopene concentrations in human pre-ovulatory follicular fluid.
        Int J Immunopathol Pharmacol. 2004; 17: 389-393
        • Ikeda S.
        • Kitagawa M.
        • Imai H.
        • Yamada M.
        The roles of vitamin A for cytoplasmic maturation of bovine oocytes.
        J Reprod Dev. 2005; 51: 23-35
        • Kemmann E.
        • Pasquale S.A.
        • Skaf R.
        Amenorrhea associated with carotenemia.
        JAMA. 1983; 249: 926-929
        • Keenan D.L.
        • Dharmarajan A.M.
        • Zacur H.A.
        Dietary carrot results in diminished ovarian progesterone secretion, whereas a metabolite, retinoic acid, stimulates progesterone secretion in the in vitro perfused rabbit ovary.
        Fertil Steril. 1997; 68: 358-363
        • Yeh J.
        • Bowman M.J.
        • Browne R.W.
        • Chen N.
        Reproductive aging results in a reconfigured ovarian antioxidant defense profile in rats.
        Fertil Steril. 2005; 84: 1109-1113
        • Symonds D.A.
        • Merchenthaler I.
        • Flaws J.A.
        Methoxychlor and estradiol induce oxidative stress DNA damage in the mouse ovarian surface epithelium.
        Toxicol Sci. 2008; 105: 182-187