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Rescue intracytoplasmic sperm injection: a systematic review

      Objective

      To assess the feasibility, efficacy, and safety of rescue intracytoplasmic sperm injection (ICSI) in cases of fertilization failure, using a scientific literature search.

      Design

      Systematic review.

      Setting

      Centers for reproductive care.

      Patient(s)

      Infertility patients with total or partial fertilization failure during an IVF cycle.

      Intervention(s)

      An electronic literature search was performed in PubMed from 1992 through May 2013. The search was then expanded by using listed references from selected articles.

      Main Outcome Measure(s)

      Pregnancy rate. The secondary outcome measures were fertilization rate, normal fertilization rate, cleavage rate, birth rate, and malformation rate.

      Result(s)

      Thirty-eight studies including 1,863 patients were included. The pooled pregnancy rate was 14.4%; 194 babies were delivered.

      Conclusion(s)

      Rescue ICSI can result in the delivery of a healthy newborn, although the pregnancy rates are low. The clinical evidence did not indicate an elevated rate of malformations, although the data are limited and incomplete.

      Key Words

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      Linked Article

      • Erratum
        Fertility and SterilityVol. 101Issue 6
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          In the article, “Rescue intracytoplasmic sperminjection: a systematic review” (Fertil Steril 2014;101:690–8), the last line of the first paragraph of the discussion should be, “Recently Ming reported a 3.52% rescue ICSI rate after total fertilization failure in a large single center study (27)” (not “3.52% of total fertilization failure” as written). The authors regret the error.
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