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Special research presentation: bmpr signaling in the mammalian oocyte improves fertilization and influences early embryo development

      Much data supports the concept that there is little to no detectable new transcription during the final stages of oocyte maturation and the initial stages of early embryo development. Therefore most of the critical events at the time of fertilization and very early embryo development rely on an orchestrated program of translation of already existing mRNAs. BMPR (Bone morphogenetic protein receptor) mRNA is increased in polysome binding during oocyte maturation. Thus, BMP signaling may be important during oocyte maturation and early embryo development, since these events are dependent on the oocyte translational program of pre-formed maternal mRNAs. We sought to assess whether activation or blockade of BMPR would affect in vitro fertilization outcomes.
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