Sequential (S) vs. monophasic (M) media impact trial (summit): a paired randomized controlled trial comparing blastulation rates or aneuploidy risk amongst sibling zygotes

      Optimal media for embryo culture continues to be an area of investigation without consensus. S media claims to be most physiologic and was developed to mimic the in vivo conditions, and consists of two phases. M media seeks to integrate the metabolic requirements of pre- and post-compaction culture into a single formulation for all phases of embryonic growth. The advantage of M formulations is that they require fewer media changes, less manipulation and stress on the embryo, and lower costs. Both culture systems have attained good outcomes, but an adequately powered controlled assessment of embryo development including usable blastulation rates and aneuploidy risk (where mosaicism may play a role) is lacking.
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