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There is growing interest in the microbiome (MB) of the reproductive tract. The vaginal
and placental MB have been partially characterized and shown to be related to obstetric
outcomes. Given the large number of unexplained IVF failures, it is plausible that
the MB of the uterus is impactful. However, to date the uterine MB is uncharacterized
and difficult given the small fraction of microbes that can be cultured successfully.
This has led to novel culture free approaches to bacterial genus detection which focus
on sequencing of 16S ribosomal DNA. This study utilizes a highly sensitive and specific
molecular genetic technology to characterize what, if any, bacteria are present in
in the uterus.
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