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Dhea supplementation results in supraphysiologic dhea-s serum levels that interfere with progesterone (P) immunoassays, resulting in spurious p elevations that may alter clinical management in IVF

      Despite a lack of prospective evidence of benefit, DHEA is being increasingly used for poor responders in an attempt to improve response to stimulation. The impact of the resulting supraphysiologic DHEA-S serum levels on sex steroid assays has not been evaluated. Since late follicular rises in P have been shown to adversely affect outcomes from fresh embryo transfers, even modest alterations in this assay may impact clinical management. This study seeks to determine the relationship between DHEA supplementation and P measurements to characterize the degree of interference with particular immunoassays.
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