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CYP1A1 3801T>C Polymorphism is Not Associated with Variations in Total Motile Sperm or Fertilization Rates with ICSI

  • R. Barnett
    Affiliations
    Division of Reproductive Endocrinology, Department of Obstetrics, Gynecology and Reproductive Science, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA
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  • J.M. Franasiak
    Affiliations
    Division of Reproductive Endocrinology, Department of Obstetrics, Gynecology and Reproductive Science, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA
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  • D. Gabriele
    Affiliations
    Reproductive Medicine Associates of New Jersey, Morristown, New Jersey, USA
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  • T.D. Gartmond
    Affiliations
    Reproductive Medicine Associates of New Jersey, Morristown, New Jersey, USA
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  • N.R. Treff
    Affiliations
    Division of Reproductive Endocrinology, Department of Obstetrics, Gynecology and Reproductive Science, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA

    Reproductive Medicine Associates of New Jersey, Morristown, New Jersey, USA
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  • R.T. Scott
    Affiliations
    Division of Reproductive Endocrinology, Department of Obstetrics, Gynecology and Reproductive Science, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA

    Reproductive Medicine Associates of New Jersey, Morristown, New Jersey, USA
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      Epidemiologic studies have evaluated the association between 3801T>C polymorphism of the CYP1A1 gene and risk for idiopathic male infertility [1]. The CYP1A1 polymorphism can alter the level of gene expression and messenger RNA stability of enzymes which play a crucial role in metabolism of compounds that have a potential reproductive toxicity in the male reproductive tract. However, there have been no studies which have evaluated the 3801T>C polymorphism and its relationship to semen analysis (SA) parameters and fertilization rates in male patients undergoing IVF/ICSI.
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