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High responders and patients with a good prognosis are not immune to the negative impact on live birth rate of elevated P on the day of triggering

      Elevated serum progesterone (P) levels above a certain threshold at the end of controlled ovarian stimulation (COS) for in vitro fertilization (IVF) have been related to poorer reproductive outcome in terms of ongoing pregnancy and live birth rates in unselected populations. Since the first concerns on this issue emerged 25 years ago, this effect has been clearly demonstrated in large population cohort studies (
      • Bosch E.
      • Labarta E.
      • Crespo J.
      • Simón C.
      • Remohí J.
      • Jenkins J.
      • et al.
      Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization— analysis of over 4000 cycles.
      ) and confirmed in a recent meta-analysis that includes >55,000 fresh IVF cycles (
      • Venetis C.A.
      • Kolibianakis E.M.
      • Bosdou J.K.
      • Tarlatzis B.
      Progesterone elevation and probability of pregnancy after IVF: a systematic review and meta-analysis of over 60,000 cycles.
      ).
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      References

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