A prospective, blinded, non-selection study to determine the predictive value of ploidy results using a novel method of targeted amplification based Next generation sequencing (NGS) for comprehensive chromosome screening (CCS)

      NGS technologies are now being utilized for CCS with promises to increase throughput and decrease costs. Unfortunately, these technologies have not been validated clinically. Most concerning is the lack of data documenting the false abnormal rate, defined as the proportion of embryos labeled as aneuploid through NGS but which would have delivered a healthy infant had they not been discarded. This study utilizes a non-selection design where embryos are transferred without knowledge of the NGS CCS result to determine the predictive value of both aneuploid and euploid results.
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