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Cumulus cell (CC) transcriptome profiling using RNA-Seq: a paired analysis of euploid sibling blastocysts

      Indicators of embryonic competence used independently or in conjunction with comprehensive chromosome screening (CCS) may facilitate embryo selection. With CCS, 60% of embryos progress to delivery. The reason the remaining morphologically normal euploid embryos fail remains to be determined. Cumulus-oocyte complexes (COCs) are strong candidates for the evaluation of oocyte quality secondary to bidirectional communication via gap junctions. The intent of this study was to investigate if differences in the CC transcriptome, as determined by RNA-Seq, are associated with embryo implantation.
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