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Microbiome at the time of embryo transfer: next generation sequencing of the 16S ribosomal subunit

      Characterization of the human microbiome has benefited from the application of powerful molecular tools utilizing the unique 16S ribosomal subunit’s hypervariable regions to greatly increase sensitivity. The microbiome of the lower genital tract can prognosticate obstetrical outcome while the upper reproductive tract remains poorly characterized. Issues outside of obstetrics are not well studied. Indeed, the microbiome at the time of embryo transfer has only been evaluated utilizing culture based technology which is known to capture only a fraction of dominant and major organisms. This study analyzes the microbiome at the time of single embryo transfer and characterizes the microbiome by reproductive outcome.
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