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Embryos from female carriers of balanced translocations do not have a higher risk of whole-chromosome aneuploidy than their age-related risk

      Given the altered chromosomal configuration of tetrads in the synaptonemal complexes of translocation carriers during meiosis, there has been concern that these couples may harbor increased risk for aneuploidy in chromosomes not directly affected by the translocation. The purpose of this study is to determine whether this interchromosomal effect (ICE) in translocation carriers increases the risk of aneuploidy beyond their age-related risk when compared to a large data set of embryos tested with comprehensive chromosome screening (CCS) at the blastocyst stage.
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