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The selective power of extended culture: blastulation rates do not appreciably decrease until very late reproductive years

      Increasing maternal age has been clearly associated with a decline in implantation rates, largely due to a decline in embryonic reproductive competence. Given that a higher proportion of embryos will ultimately fail, there is a logical need for enhanced selection paradigms to identify those embryos with the greatest chance of progressing to delivery. Some clinicians and embryologists have cautioned against the use of extended culture or application of trophectoderm biopsy with the use of comprehensive chromosomal screening (CCS) over concerns that all embryos will fail to blastulate. This study seeks to determine the impact of age on embryonic performance in vitro.
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