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Antimüllerian hormone: correlation with age and androgenic and metabolic factors in women from birth to postmenopause

  • Linlin Cui
    Affiliations
    Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China

    Key Laboratory for Reproductive Endocrinology of Ministry of Education, People's Republic of China, Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China

    National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, People's Republic of China
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  • Yingying Qin
    Affiliations
    Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China

    Key Laboratory for Reproductive Endocrinology of Ministry of Education, People's Republic of China, Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China

    National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, People's Republic of China
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  • Xuan Gao
    Affiliations
    Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China

    Key Laboratory for Reproductive Endocrinology of Ministry of Education, People's Republic of China, Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China

    National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, People's Republic of China
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  • Jun Lu
    Affiliations
    Qilu Securities Institute for Financial Studies, Shandong University, Jinan, People's Republic of China
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  • Ling Geng
    Affiliations
    Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China
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  • Lingling Ding
    Affiliations
    Reproductive Medical Hospital Affiliated to Shandong University, Jinan, People's Republic of China
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  • Zhongyu Qu
    Affiliations
    Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China
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  • Xiruo Zhang
    Affiliations
    Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China

    Key Laboratory for Reproductive Endocrinology of Ministry of Education, People's Republic of China, Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China

    National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, People's Republic of China
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  • Zi-Jiang Chen
    Correspondence
    Reprint requests: Zi-Jiang Chen, M.D., Ph.D., Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jingliu Road 157, Jinan 250001, People's Republic of China.
    Affiliations
    Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China

    Key Laboratory for Reproductive Endocrinology of Ministry of Education, People's Republic of China, Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China

    National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, People's Republic of China

    Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, People's Republic of China
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      Objective

      To study the age-specific distribution of antimüllerian hormone (AMH) and describe the association of AMH with androgenic and metabolic profiles at different ages.

      Design

      Cross-sectional study.

      Setting

      University hospital.

      Patient(s)

      A total of 6,763 Chinese women from birth to menopause.

      Intervention(s)

      None.

      Main Outcome Measure(s)

      Anthropometric parameters (height, weight, and blood pressure), and levels of AMH and testosterone, glucose metabolism, and lipid profiles.

      Result(s)

      According to the level of AMH, four age phases were established: childhood (0–10 years), adolescence (11–18 years), reproductive age (19–50 years), and advanced age (≥51 years). During childhood and adolescence, AMH levels increased, reaching a peak at 18 years. A decline occurred thereafter during the reproductive-age period until the age of 50 years, and it remained at a low level above 0 onward. We found that AMH was negatively correlated with testosterone in childhood (r = −0.25), but was positively correlated with testosterone and the free androgen index in adolescence (r = 0.30; r = 0.26, respectively) as well as during the reproductive phases (r = 0.28; r = 0.31, respectively). No correlation was observed between AMH and body mass index, fasting blood glucose, fasting insulin, the homeostasis model assessment, total cholesterol, triglycerides, low-density lipoprotein, or high-density lipoprotein at any phase.

      Conclusion(s)

      From birth to 18 years, AMH increases, then it declines thereafter, indicating changes of ovarian maintenance. A positive relationship between androgenic profiles and AMH during adolescence and reproductive years implies a synchronism between androgens and ovarian reserve.

      Key Words

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      Linked Article

      • Erratum
        Fertility and SterilityVol. 109Issue 5
        • Preview
          In the article by Cui et al., “Antimüllerian hormone: correlation with age and androgenic and metabolic factors in women from birth to postmenopause” (Fertil Steril 2016;105:481-5), the unit of AMH should be μg/L instead of mg/L. The number values in the article are correct. The authors apologize for the error.
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