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Aneuploidy is a major contributor to decreased reproductive potential and is more prevalent with increasing age. Additionally, there is a surprisingly high occurrence of aneuploidy in infertile patients at very young ages (1). Donor oocytes are commonly used as a therapeutic option for older women. However, observed aneuploidy in very young IVF patients suggests young patients may also be prone to higher rates of aneuploidy. A large comparison of aneuploidy rates in infertile patients and oocyte donors utilizing a 24 chromosome aneuploidy platform has not been done.
To determine the rate of aneuploidy in the donor population compared with the general IVF population.
Materials and methods
Patients from a single institution who underwent donor oocyte cycles with comprehensive chromosome screening (CCS) from 2009 through 2014 were included. Oocyte donors underwent routine ovarian stimulation and oocyte retrieval. After extended culture and trophectoderm biopsy, CCS was performed utilizing a validated platform. Chi-squared was utilized to compare aneuploidy rates between age matched donors and a large reference infertility population which excluded donors.
169 women met inclusion criteria. Average age of donors was 26 (range 22-31), and average number of blastocysts analyzed was 8.7 (range 1-32). The rate of aneuploidy overall is significantly higher in the general IVF population compared to the donor population, 26.6% compared to 19.2% (p<0.0001). When looking specifically at women younger than 26, the rate of aneuploidy in the general IVF population is 34% compared with 18.5% in the donor population (p<0.0001). Above age 27, there is no clear difference seen (Figure 1).
The rate of aneuploidy is higher in the infertile IVF population when compared to the donor population at young ages. However, it is notable that the prevalence of aneuploidy in the donor population was still approximately 20%. While donor oocyte does provide a lower rate of aneuploidy than in the infertile population, the risk is not completely avoided and preimplantation genetic screening still provides a meaningful method of embryo selection.
Franasiak, Jason M., et al. The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening. Fertility and Sterility. Volume 101, Issue 3: 656-663.e1.