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Toward a better understanding of the oocyte donation/pre-eclampsia connection

      In this issue of Fertility and Sterility, Letur et al. (
      • Letur H.
      • Peignéb M.
      • Ohlc J.
      • Cédrin-Durnerind I.
      • Mathieu-D’Argente E.
      • Schefflerf F.
      • et al.
      Hypertensive pathologies and egg donation pregnancies: results of a large comparative cohort study.
      ) describe their findings comparing the rates of pre-eclampsia in women undergoing standard IVF to those becoming pregnant with donated oocytes (OD). They enrolled from seven French centers over a 7-year period. Only patients whose pregnancies were confirmed as singleton at 7–8 weeks were included, eliminating the confounding effects of multiple gestation or even clinically apparent vanishing twins. Accordingly, the control group was not of natural conceptions, allowing most IVF laboratory and stimulation variables to be constant between the 2 groups, albeit endometrial development occurred via different conditions. Data on 580 women, 217 OD and 363 IVF controls, were obtained directly from patients’ assisted reproductive technology and hospital records. The study objective was to determine the rate of pre-eclampsia in each group, and there were enough patients for adequate statistical power. Typically recipients are older than women undergoing traditional IVF, but here the groups were matched for age, to an average of 34.5 years. Matching was also for parity and whether the transfer was fresh or frozen.
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        Hypertensive pathologies and egg donation pregnancies: results of a large comparative cohort study.
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