No diagnosis after day 3 biopsy: indicative of embryo prognosis or biopsy error

      Although more IVF centers are adopting trophectoderm biopsy for PGS instead of “cleavage stage” (D3), some clinics still offer these two options to their patients. One of the main challenges with D3 biopsy procedures is the limited amount of genetic material available to perform analysis. Limited genetic material may give a no result diagnosis or a chaotic profile, which are common in apoptotic cells and/or DNA damage during biopsy. These results leads to inconclusive diagnoses posing a burden on reproductive care providers on whether to biopsy these “non conclusive” embryos or to discard them. The aim of this study was to determine the likelihood that a D3 biopsy without a diagnosis, will have a genetically assigned diagnosis when allowed to grow to day 5/6, and to compare that diagnosis to a control group of blastocysts of similar maternal age, to determine if blastocysts resulting from day 3 “no result” embryos have a poorer prognosis than the control group.
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