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Although more IVF centers are adopting trophectoderm biopsy for PGS instead of “cleavage
stage” (D3), some clinics still offer these two options to their patients. One of
the main challenges with D3 biopsy procedures is the limited amount of genetic material
available to perform analysis. Limited genetic material may give a no result diagnosis
or a chaotic profile, which are common in apoptotic cells and/or DNA damage during
biopsy. These results leads to inconclusive diagnoses posing a burden on reproductive
care providers on whether to biopsy these “non conclusive” embryos or to discard them.
The aim of this study was to determine the likelihood that a D3 biopsy without a diagnosis,
will have a genetically assigned diagnosis when allowed to grow to day 5/6, and to
compare that diagnosis to a control group of blastocysts of similar maternal age,
to determine if blastocysts resulting from day 3 “no result” embryos have a poorer
prognosis than the control group.
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