Advertisement

Androgens, estrogens, and cardiovascular disease: considerations for women with polycystic ovary syndrome

      Worldwide, cardiovascular disease (CVD) is the leading cause of death and disability. A 2015 review of the available literature regarding sex differences in cardiovascular risk factors noted that although CVD is often regarded as a disease of men, it is, in fact, more common in women (
      • Appelman Y.
      • van Rijn B.B.
      • Ten Haaf M.E.
      • Boersma E.
      • Peters S.A.
      Sex differences in cardiovascular risk factors and disease prevention.
      ). The review examined the impact of traditional risk factors, such as hypertension, smoking, obesity, diabetes, and elevated cholesterol, on CVD outcomes and concluded that some factors, such as prolonged smoking and diabetes, were significantly more hazardous for women (
      • Appelman Y.
      • van Rijn B.B.
      • Ten Haaf M.E.
      • Boersma E.
      • Peters S.A.
      Sex differences in cardiovascular risk factors and disease prevention.
      ). The review also examined the emerging evidence for the existence of CVD risk factors that are limited to women, such as gestational diabetes, gestational hypertension, early menopause, and polycystic ovary syndrome (PCOS).
      To read this article in full you will need to make a payment

      References

        • Appelman Y.
        • van Rijn B.B.
        • Ten Haaf M.E.
        • Boersma E.
        • Peters S.A.
        Sex differences in cardiovascular risk factors and disease prevention.
        Atherosclerosis. 2015; 241: 211-218
        • Penn C.
        • Chan J.
        • Mesaros C.
        • Snyder N.W.
        • Rader D.J.
        • Sammel M.D.
        • et al.
        Association of serum androgens and coronary artery calcium scores in women.
        Fertil Steril. 2019; 112: 586-593
        • Pinola P.
        • Piltonen T.T.
        • Puurunen J.
        • Vanky E.
        • Sundstrom-Poromaa I.
        • Stener-Victorin E.
        • et al.
        Androgen profile through life in women with polycystic ovary syndrome: a Nordic multicenter collaboration study.
        J Clin Endocrinol Metab. 2015; 100: 3400-3407
        • Fauser B.C.
        • Tarlatzis B.C.
        • Rebar R.W.
        • Legro R.S.
        • Balen A.H.
        • Lobo R.
        • et al.
        Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM–Sponsored 3rd PCOS Consensus Workshop Group.
        Fertil Steril. 2012; 97: 28-38.e25
        • Meun C.
        • Franco O.H.
        • Dhana K.
        • Jaspers L.
        • Muka T.
        • Louwers Y.
        • et al.
        High androgens in postmenopausal women and the risk for atherosclerosis and cardiovascular disease: the Rotterdam study.
        J Clin Endocrinol Metab. 2018; 103: 1622-1630

      Linked Article