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Diagnosing endometriosis by measuring plasma micro ribonucleic acids: it may take a miRacle

      Endometriosis is a common cause of infertility, dyspareunia, dysmenorrhea, and chronic pelvic pain. Apart from detecting an endometrioma by pelvic imaging, current diagnosis of endometriosis is made surgically by the visualization of implants in the pelvis. Surgery is expensive and carries risk; this explains the often decade-long delay in diagnosing endometriosis. Meanwhile, empiric treatment of endometriosis for all patients presenting with pelvic pain is a misuse of resources and delays the diagnosis and treatment of alternative causes of pelvic pain. A noninvasive diagnostic biomarker for endometriosis would benefit patients and providers by permitting low-risk, cost-effective, and prompt detection of the disorder. Such a marker might enable early and titrated medical treatment depending on disease severity. A biomarker would benefit the research community by identifying affected patients early in the disease process when study of disease progression, and clinical trials, might be possible.
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      References

      1. Papari E, Noruzinia M, Kashani L, Foster WG. Identification of candidate miRNA markers of endometriosis through next generation sequencing and qRT-PCR. Fertil Steril. 2020;113:1232‐41.

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