Dietary patterns and ovarian reserve among women attending a fertility clinic


      To investigate the associations between dietary patterns and antral follicle count (AFC), a marker of ovarian reserve.


      Prospective cohort study.


      Fertility center at an academic hospital.


      A total of 363 women seeking preconception evaluation and infertility care at the Massachusetts General Hospital who participated in the Environment and Reproductive Health Study.


      None. At enrollment, women reported diet through a food frequency questionnaire, from which we computed three dietary pattern adherence scores: the Mediterranean diet, the Fertility diet, and the Profertility diet.

      Main Outcome Measure(s)

      The AFC was assessed with a transvaginal ultrasound performed on the third day of an unstimulated menstrual cycle or on the third day of a P withdrawal bleed.


      Higher adherence to the three dietary patterns examined were unrelated to AFC. The multivariable adjusted AFC means and 95% confidence intervals for women in the highest compared with the lowest quartile of adherence score were 13.9 (13.0–14.9) and 13.5 (12.6–14.4) for the Mediterranean diet, 14.0 (13.2–14.9) and 13.5 (12.7–14.3) for the Fertility diet, and 12.5 (11.6–13.5) and 13.3 (12.5–14.2) for the Profertility diet.


      Dietary patterns were unrelated to AFC among a cohort of women presenting at a fertility center. Due to the limited and heterogeneous current evidence, it is important to evaluate this association in further studies, and in particular among women from the general population.
      Patrones dietéticos y reserva ovárica entre mujeres que concurren a una clínica de fertilidad.


      Investigar las asociaciones entre los patrones dietéticos y el recuento de folículos antrales (AFC), un marcador de reserva ovárica.


      Estudio prospectivo de cohorte.


      Centro de fertilidad en un hospital académico.


      Un total de 363 mujeres buscando evaluación preconcepcional y atención por infertilidad en el Hospital General Massachusetts que participaron en el Estudio Ambiental y de Salud Reproductiva.


      Ninguna. En la inclusión, las mujeres informaron su dieta a través de un cuestionario de frecuencia alimentaria, del cual calculamos tres puntuaciones de adherencia a los patrones dietéticos: dieta Mediterránea, dieta de Fertilidad, y dieta Profertilidad.

      Medida(s) de Resultado Principal

      El AFC fue evaluado con ecografía transvaginal realizada en el tercer día de un ciclo menstrual no estimulado o en el tercer día de una hemorragia por deprivación P.


      Mayor adherencia a los tres patrones dietéticos evaluados no estaban relacionados al AFC. Las medias de AFC ajustadas multivariante e intervalos de confianza 95% para las mujeres en el cuartil más alto comparado con el cuartil más bajo de puntuación de adherencia fueron 13.9 (13.0-14.9) y 13.5 (12.6-14.4) para la dieta Mediterránea, 14 (13.2-14.9) y 13.5 (12.7-14.3) para la dieta de Fertilidad, y 12.5 (11.6-13.5) y 13.3 (12.5-14.2) para la dieta Profertilidad.


      Los patrones dietéticos no están relacionados con el AFC entre mujeres que concurren a un centro de fertilidad. Debido a la evidencia actual heterogénea y limitada, es importante evaluar esta asociación en estudios futuros, y en particular entre mujeres de la población general.

      Key Words

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